Bayer Aktiengesellschaft

Hans-Egon Kunzel

Gerhard D Wolf

Gunther Nischk

Robert Bierling

Siegfried Petersen

Dieter Steinhoff

2-Phenyl-4(3H)-quinazolones bearing a urethane or thiourethane group on the 2-phenyl substituent, a second urethane or thiourethane group on the benzo ring of the quinazolone nucleus and an alkyl, cycloalkyl or phenyl group in the 3-position are prepared by treating the corresponding bis-amino compound with an acid derivative or the corresponding bis(isocyanate) or bis(isothiocyanate) with an alcohol. The compounds, of which 2-[3'-(methoxycarbonylamino)-phenyl]-3-phenyl-6-methoxycarbonylamino-4-(3H )-quinazolone is a typical embodiment, are cytostatic agents.

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Dormagen, Germany

Hans-Egon Kunzel