Fresenius Ag

Annemarie Schlogl Gmbh & Co. Kg

Hans-Dietrich Polaschegg

Bernd Mathieu

Klaus Metzner

Walter Pieper

Detlef Westphal

Bernd Steinbach

Wolfgang Allendorfer

Reinhard Hahnel

Daniel Weber

Ulrich Faeser

Claus Walter

Dieter Mahn

Dieter Husar

Hans Walter

Hans-Helmut Lewinsky

Wendelin Backhaus

Joachim Manke

The invention concerns a bag to accommodate solid or fluid concentrate which is used to prepare dialysis fluid using a dialysis machine. The bag consists of a bag body and at least one opening, whereby the opening is sealingly surrounded by a plug component (220). In the coupled state with a second plug component (210), the plug component (220) forms a flow connection with the interior of the bag. The plug component also has coupling means (276, 278) which are suitable to be connected with a second complementary plug component (210), which is disposed on the dialysis machine. By means of the plug connector, in the coupled state, a first flow path is formed from the dialysis machine to the interior of the bag and a second flow path is formed back from the interior of the bag to the dialysis machine.

Container for collection of concentrate

An apparatus and a method are provided for collecting samples of used dialysate during hemodialysis treatments. A fluid sample is branched off from the main flow of used dialysate into a sample receiving container. The branching off of the sample flow, i.e. withdrawal of the fluid sample, is either time- or volume-controlled so that during the course of a dialysis treatment a predetermined number of fluid samples are withdrawn, whereby the total sample volume has a prescribed ratio relative to the total volume of used dialysate. The recirculation and sample withdrawal conduit is selectively attachable to the sample receiving container for sample collection, or to the inlet of the hemodialysis device to form a recirculation loop for a disinfection cycle. A disinfectant cartridge can be interposed between the recirculation conduit and the hemodialysis device inlet.

Method and apparatus for determining the quantity of oremic toxins

A gas exchange device (100) with an extracorporeal blood circuit (102) in which a blood pump (110) is connected, with a CO.sub.2 exchange unit (112), and an oxygenator (128), whereby the gas exchange unit (112, 128) is in each case divided by a hydrophilic, water-wet membrane (114, 130) into a blood chamber (116, 132) and a gassing chamber (118, 134) which is under positive transmembrane pressure.

Gas exchange apparatus

A method and apparatus for monitoring the operability of components in a hemodialysis apparatus during dialysis treatment. The dialyzer is isolated from the dialyzing liquid circuit for a time interval during dialysis treatment. During the isolation time interval, the dialyzing liquid circuit pressure is measured and monitored to detect deviations from a mean dialyzate operating pressure. The isolation is repeated periodically, with the time period between isolation intervals dependent upon the ultrafiltration coefficient of the dialyzer. This method may be performed automatically by a microprocessor in the hemodialysis apparatus.

Process for determining the operability of the structural components in

In a dialysis apparatus having a dialyzer and a single balance chamber, the internal volume of the balance chamber is preferably at most 2/3 of the volume of the dialysis fluid chamber within the dialyzer. As a result, during the dialysis fluid recirculation cycle, at most 2/3 of the volume of fluid within the dialysis fluid chamber will be replaced by fresh dialysis fluid. Preferably, the duration of the recirculation cycle is approximately equal to the duration of the balance chamber filling cycle.

Hemodialysis apparatus having a single balance chamber and method of

Implantable infusion apparatus comprising a chamber sealed by a septum and having an outlet aperture leading therefrom, to which a catheter tube is connected. A wire anchored in the chamber base projects into the catheter lumen, forming a ring slot whose diameter is smaller than the average size of a punched out particle. The wire thus serves as a particle retention means.

Implantable apparatus

A hemodialysis device (10) which features an improved disinfection apparatus. Before disinfection begins, a container (30) of disinfectant (36) is interposed into the dialysis fluid circulation system in place of the dialyzer. The dialysis fluid circulation system is shunted, and the disinfecting solution which is present in this closed circulation system is flushed out of the container (30) and through the entire path of the dialysis fluid, in order to achieve a complete cleaning of the hemodialysis device (10). It is possible to use solid, soluble disinfectant (36) as well as liquid disinfectant.

Apparatus for disinfection of hemodialysis devices with a powdered

An apparatus for preparing a medicinal solution, in particular dialysis solution, from pulverulent concentrate and water comprises a water source (12) from which a first conduit (14) is led to a container which contains the powder and from which a second conduit (20) into which a first measuring cell (22) and a concentrate pump (24) are connected leads to a mixing point (28). Said mixing point (28) is located in a third conduit (26) which leads from the water source to a consumer; downstream of the mixing point (28) a second measuring cell (30) is provided for monitoring the composition of the finished dialysis solution. Since the two measuring cells (22) and (30) lie in different conduits in which solutions of different composition are conveyed, there is no possibility whatever of confusions between concentrates of the same initial conductivity but different final conductivity after dilution with water.

Apparatus for preparation of a medicinal solution

To determine in simple manner the change of the intravascular blood volume during filtration, in the extracorporeal blood circuit (2) of a blood purification apparatus at least one ultrasonic sensor (15) is arranged which is connected to an evaluating unit (18) which is configured in such a manner that at the start of the filtration a first ultrasonic signal is stored and during the filtration the change of the ultrasonic signals is determined. From the change of the ultrasonic signals the change of the hematocrit is determined and from this the change of the intravascular blood volume is deduced.

Measuring the change of intravascular blood volume during blood

This invention relates to a pressure equalizing vessel for a hemodialysis concentrate. To ensure the supply of concentrate at a constant pressure to the concentrate pump for preparing dialysis fluid, even in cases where a central concentrate supply system is used, the present invention suggests that a cylindrical upright vessel 1 whose lower portion is provided with a concentrate inlet and whose upper portion has arranged thereon a venting means 4 should have inserted thereinto a concentrate suction tube 7 which is equipped with at least one level sensor (FIG. 1).

Pressure equalizing vessel for a hemodialysis concentrate

This invention relates to a method for the in-vivo determination of hemodialysis parameters. To carry out hemodialysis with the greatest efficiency and safety, it is inter alia necessary to know the clearance of the dialyzer. To be able to determine the same in vivo, the invention provides a method in which the electrolyte transfer of the dialysis fluid is measured by means of a measuring device at two different predetermined dialysis fluid ion concentrations and the dialysance is determined on the basis thereof, which dialysance is numerically equal to the clearance.

Method for the in-vivo determination of hemodialysis parameters

The invention is directed to a process and an arrangement for control of blood pumps in an extra-corporeal circuit provided to a single needle arrangement. In order to avoid recirculation, in accordance with the invention it is provided that the arterial and the venous pumps run at an increased throughput rate at the beginning of each pumping phase.

Process for controlling blood pumps in the extra-corporeal circuit of a

The invention concerns a hemodialysis apparatus with a hemodialyser (10), which on the blood side has a blood pump (30) to convey blood from a patient to the dialyser (10) and on the dialysis solution side has a dialysis solution pump (20) to convey dialysis solution to the dialyser. The hemodialysis apparatus has a control device (100) whereby a signal derived from the magnitude of the blood flow is fed to the said device on the input side and whereby the said device gives a signal on the output side as a function of the blood flow in order to adjust the dialysis solution flow. With an automatic control device of this type dialysis concentrate, prepared water and energy can be saved. The predetermined control function can be a linear function. It can also be given in the form of numerical data which is fed into a matrix in the control device (100) which for every blood flow of one particular dialyser (10) gives a dialysis solution flow at which a certain percentage of clearance is achieved when the dialysis solution flow is continuous.

Hemodialysis apparatus with automatic adjustment of dialysis solution

An implantable device for the dosed administration of medicaments to the human body includes a first chamber for storing a medicament and having a refill opening sealed by a pierceable septum and an outlet opening communicating with an outlet catheter, a second chamber separated from the first chamber by a flexible diaphragm which serves to apply pressure to the medicament, and a hollow fiber capillary filter disposed at the outlet opening of the first chamber to act as a filter.

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Oberursel, Germany

Hans-Dietrich Polaschegg