Pharis Biotec Gmbh

Haemopep Pharma Gmbh

Biovision, Ag

Electrophoretics Limited

Hans-Dieter Zucht

Wolf-Georg Forssmann

Karsten Kuhn

Knut Adermann

Norbert Lamping

Cornelia Liepke

Manfred Raida

Sasa Koncarevic

Harmut Selle

Michael Jürgens

Gabriele Heine

Rüdiger Hess

Hans-J&uuml;rgen M&auml;gert

Stefan Selzer

The invention relates to defined peptides and the quantitative determination thereof in body fluids of patients suffering from progredient chronic dementia, in relation to the concentration of said peptides in a control group. The inventive peptides come from a protein precursor having the corresponding gene, are processed in a specific manner, and are optionally post-translationally modified, especially phosphorylized. An increase in the concentrations of these peptides or the corresponding non-processed protein indicates progredient chronic dementia. Progredient chronic dementia is detected by identifying the peptides and/or the protein individually or in combinations. The invention also relates to the use of said peptides for controlling the course of progredient chronic dementia and for the prognosis of progredient chronic dementia, especially for complementing or replacing mini-mental scores, and for developing therapeutic agents to combat progredient chronic dementia such as Alzheimer's disease.

Method for detecting a progressive, chronic dementia disease, and corresponding peptides and detection agents

Pepetides having bifidogenic properties are obtainable by the process of adding proteases to cow'milk or human milk, followed by incubation, centrifugation, acidification, purification by reverse phase HPLC and cation-exchange HPLC, culturingandin the presence of collected bifidogenic fractions, and isolation of the peptides having bifidogenic properties, and the isolated peptides can be amidated, acetylated, sulfated, phosphorylated, glycosylated, oxidized, or fragmented and still maintain their bifidogenic properties, and combination peptides having bifidogenic properties are obtainable by chemically bonding the peptides having bifidogenic properties, the amidated, acetylated, sulfated, phosphorylated, glycosylated, oxidized, or fragmented peptides having bifidogenic properties, or combinations thereof.

Bifidogenic peptides

Antibiotic peptides from bovine milk

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Hannover, Germany

Hans-Dieter Zucht