Astra Lakemedel Aktiebolag

Becton Dickinson and Company Limited

Astra Lakemedel Ab

Hans C Evers

Berndt F Broberg

Randal A Hoke

John D DeNuzzio

Bernt Fredrick Broberg

A user activated iontophoretic device of the present invention includes an electrode assembly, an electrode reservoir and at least one drug reservoir. The device is divided or otherwise separated into at least two portions, with one portion containing the electrode reservoir and the other containing the drug reservoir, which may include a medication in a dry form. In one embodiment, the two portions are each contained in separate compartments of a pouch. In another embodiment, the portions are contained in a single compartment and divided by a barrier. A method of activating the device includes causing the two portions to come into electrical conducting contact with one another to at least partially hydrate one of the reservoirs. This can be accomplished, for example, by either folding the device to bring the two portions into contact with one another or simply by removing the barrier dividing the two portions. In the alternative, the device may include two separate portions which can be brought together to activate the device. In this way, the device is suitable for use to deliver a high dose efficiency, while providing a commercially suitable shelf-life.

User activated iontophoertic device

The invention relates to a filled, thermoplastic unit dose injection solution container the outlet opening of which is sealed. The outlet opening is designed to fulfill the specifications for a standardized female cone intended to be non-leakingly connected to a correspondingly standardized male cone of a syringe in order to transfer the injection solution directly into the syringe. The unit dose container is preferably non-resealably sealed.

Filled unit dose container

The present invention relates to pharmacological active preparations, especially local anesthetic preparations and deals with the problem of i a obtaining a solution of a local anesthetic agent in the form of its base, where the concentration is higher than otherwise possible. This problem has been dissolved according to the present invention thereby that one local anesthetic agent in the form of its base and as such having a melting point of 30.degree. to 50.degree. C., preferably prilocaine or tetracaine, is provided with one other local anesthetic agent in the form of its base and as such having a melting point of above 30.degree. C., preferably above 40.degree. C., preferably bensocaine, lidocaine, bupivacaine, mepivacaine, etidocaine or tetracaine which agents when brought and heated together form a homogenous oil having a melting of preferably below 40.degree. C., more preferably below 25.degree. C.

Local anesthetic mixture for topical application, process for its

Local anesthetic mixture for topical application and method for

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Sodertalje, Sweden

Hans C Evers