The General Hospital Corporation

Wahrheit, LLC

Hans C Breiter

Bruce R Rosen

David Borsook

Lino Becerra

John J A Marota

Joseph B Mandeville

Barry E Kosofsky

A method analyzes preferences of one or more participants. Each of the participants may be presented with a plurality of evaluation items that illustrate various marketing options. Response data from the participants that indicates at least an approach, if any, toward the evaluation items is obtained. An approach entropy value may be generated for the marketing options based on the response data for each participant. A relative preference order for each participant for the marketing options may be determined from the generated approach entropy values.

System and method for determining relative preferences for marketing, financial, internet, and other commercial applications

System and method for determining relative preferences

A method for measuring indices of brain activity includes non-invasively obtaining signals of central nervous system (CNS) activity, localizing signals to specific anatomical and functional CNS regions, correlating the signals from pain and reward brain regions, and interpreting the correlation results. The results of interpreting the correlation results can be used for objectively measuring, in individual humans or animals, their responses to motivationally salient stimuli including but not limited to stimuli which are internal or external, conscious or non-conscious, pharmacological or non-pharmacological therapies, and diseased based processes. This method for measuring brain activity in reward/aversive central nervous system regions, can further be used to determine the efficacy of compounds.

Method and apparatus for objectively measuring pain, pain treatment and other related techniques

The invention provides methods for inhibiting psychostimulant-induced or nicotine-induced craving of additional psychostimulants (e.g., cocaine or amphetamine) or nicotine. In these methods, D1-like antagonists or D1-like agonists are administered to a patient dependent on psychostimulant drugs or nicotine and therefore susceptible to, or suffering from, such a craving. Also disclosed is an animal model system useful for measuring the ability of test compounds to inhibit pyschostimulant-induced or nicotine-induced cravings in humans.

Inhibition of psychostimulant-induced and nicotine-induced craving

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Lincoln, MA, United States of America

Hans C Breiter