Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Merck Patent Gesellschaft

Nanomics Technologies Gmbh

Hanns Wurziger

Guido Melzer

Sabine Bernotat-Danielowski

Norbert Schwesinger

Joachim Gante

Horst Juraszyk

Peter Raddatz

Guido Pieper

Michael Schmelz

Dieter Dorsch

Werner Mederski

Klaus-Otto Minck

Rolf Gericke

Rochus Jonas

Manfred Baumgarth

Rolf Bergmann

Hans-Jochen Schliep

Jacques De Peyer

Inge Lues

Hans J Enenkel

Joeran Stoldt

Gunther Hausler

Michael Kloft

Christos Tsaklakidis

Hans-Peter Buchstaller

Bertram Cezanne

Matthias Wiesner

Michael Hohmann

Claus Fittschen

Kai Fabian

Juergen Harting

Detlef Pauluth

Andreas Taugerbeck

Johannes Gleitz

Axel Jansen

Helmut Prucher

Christoph Van Amsterdam

David Maillard

Andreas Schober

Jurgen Harting

Soheila Anzali

Gregor Schlingloff

G&uuml;nter Brenner

Holger Deppe

Alexander Gross

Beate Diefenbach

Dirk Tomandl

Beate Kretschmer

Günter Brenner

H&ouml;rst Juraszyk

Thomas Greve

Gerd Quenzer

Horst Juraczyk

Lothar Spreng

Mirco Arndt

The invention relates to compounds of the formula (I), in which R, R, R, R, Y and A have the meanings indicated, and to processes for the preparation thereof and to the use thereof for the preparation of medicaments. 

Oxaphenanthrene derivatives

The invention relates to a method for production of compounds of formula (I), where X has the meaning given in claimand precursors for the same.

Process for the production of N-arylmorpholinones

Novel compounds of the formula (I), in which D, W, X, Y, T, m and Rhave the meaning indicated in Patent claim, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.

Carboxamides

In a device for the temperature control of microcomponents, in particular micro-reactors, which preferably have a plate-shaped design and preferably consist of silicon, at least one microcomponent is pressed against a temperature-control element in a holder. A flat heat-conducting connection exists between the microcomponent and the temperature-control element.

Device for controlling the temperature of chemical microreactors

The present invention relates to processes for the bromination of organic compounds, and to bromination microreactors for carrying out these processes.

Method for brominating organic compounds

The present invention relates to a process for the reduction of aliphatic, aromatic or heterocyclic organic compounds by means of hydrides and/or derivatives thereof.

Method for reducing organic compounds in microreactor by means of hydrides and/or the derivatives thereof

Microwells, which are open on both sides and are arranged two-dimensionally in a microwell matrix (), are hermetically closed by pressure on both sides using plugs () covered with a sealing sheet (). A layer of elastic material (), which is arranged between the plug () and the sealing sheet (), guarantees uniform pressure on all the microwells of a microwell matrix () which is loosely held by a frame structure (). Continuous peripheral elevations (), which protrude in both directions at right angles to the plane of the microwell matrix (), ensure that the deformable thin layer of elastic material () does not escape sideways between the plug () and the microwell matrix () during the pressing process. A plurality of microwell matrices () are held simultaneously by the frame structure () and are hermetically closed by a corresponding number of allocated plugs (), which are fastened to a base plate () and a cover plate (), respectively.

Device used in parallel microsynthesis

The present invention relates to a process for the dehydration of organic compounds to give unsaturated compounds.

Method for dehydrating organic compounds in a microreactor

In a device for connecting microcomponents, in particular microreactors, which preferably have a plate-shaped design and preferably consist of silicon, a sealing plate having apertures which correspond to apertures in the microcomponents is arranged between the microcomponents.

Device for connecting microcomponents

The invention relates to a method for the 1,3 dipolar cycloaddition of organic compounds, characterized in that the reaction is carried out in a microreactor.

Method for the 1,3 dipolar cycloaddition of organic compounds in a microreactor

A device for the emulsification and separation of small amounts of immiscible liquid phases has essentially a cover plate (), which can be tightly connected to a base plate (), where microchannels () in the form of grooves are cut out on the inner surface () of the base plate () and/or cover plate (). In a mixing zone, two microchannels () run in a wave shape crossing one another a number of times. In a subsequent separation zone, they run essentially straight combined in a common microchannel (). The otherwise tightly sealed-off microchannels () can be filled and emptied again via inlet apertures () and outlet apertures ().

Emulsifying and separating device for liquid phases

The present invention relates to a process for the preparation of indoles.

Method for producing indoles

An interconnection support for plate-like microcomponents () has a support rail () which is attached to a support plate (). An insertion slot () for the support rail () accommodates an insertion edge () of a plate-like microcomponent (). Like connections (), which can be connected to associated connections () in an outside () of the plate-like microcomponent (), are provided in at least one side wall () of the insertion slot () of the support rail ().

Interconnection support for plate-like microcomponents

The invention generally relates to a method of formylating organic compounds in a microreactor.

Method for formulating organic compounds

The present invention relates to a novel process for the nitration of organic compounds, preferably of aromatic and heteroaromatic compounds, using nitrating reagents which are known from the literature and new types of nitrating reagents.

Nitration in a static micromixer

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Darmstadt, Germany

Hanns Wurziger