Bayer Aktiengesellschaft

Ludwig, Hanns

Bode, Liv

Hanns Ludwig

Walter Strube

Peter Thein

Liv Bode

Gholamreza Darai

One aspect of the present invention is directed to a method for detecting acute Borna Disease Virus (BDV) infections. According to the invention, the presence of heterodimers of p24 BDV phosphoprotein and p40 BDV nucleoprotein in a sample is determined by means of antibodies of both proteins using a sandwich ELISA. The invention also relates to a diagnostic kit for a sandwich ELISA for detecting mute BDV infections. Said kit uses a antibody of p24 BDV phosphoprotein and a second primary antibody of p40 BDV nucleoprotein, at least one reporter-molecule-labelled secondary antibody, means for immobilising a primary antibody on a surface, and instructions for carrying out the method according to the invention. The invention also relates to the combination of the method according to the invention and the new diagnostic kit with known methods for detecting circulating immune complexes (CIC) and antibodies. Acute BDV infections are thus distinguished from chronic and latent ones (humans and animals), allowing, for example, differential diagnosis and treatment monitoring for diseased individuals but also the identification of health risks depending on infection status in healthy carriers.

Method for detecting acute Borna disease virus (BDV) infections, and diagnostic kit therefor, in particular in combination with methods for distinguishing acute from chronic and latent BDV infections, and diagnostic kits therefor

The invention relates to equine herpesviruses (EHV) which contain foreign DNA elements in addition to the genome sequences necessary for the replication thereof, to process for the preparation thereof and to the intermediates employed therein, and to the use thereof in vaccines against EHV infections.

Equine herpesviruses (EHV) which contain foreign DNA, process for the preparation thereof and the use thereof in vaccines

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Berlin, Germany

Hanns Ludwig