Transgene S.a.

Hanno V J Kolbe

Thierry Delair

Tilman Achstetter

Otmane Boussif

Ulla B Rasmussen

Laurent Veron

G&uuml;nther Kreil

The invention concerns novel cationic polymers of formula (I) in which n is a whole number between 0 and 5 and p is a whole number between 2 and 20,000, more particularly p ranges between 10 and 18,000, and advantageously between 200 and 1,000, characterized in that: at least 10%, advantageously 30 to 80%, preferably 70%, of the free NH functions are substituted by identical or different hydrophilic R groups; said cationic polymer can further comprise at least a targeting element associated covalently or not with the free NH functions and/or said hydrophilic R groups provided that said cationic: polymer contains at least 20%, preferably at least 30%, of free NH functions. The invention also concerns a complex comprising at least said cationic polymer associated with at least a therapeutically active substance, in particular a nucleic acid comprising at least a negative charge. The invention is useful for transferring a nucleic acid into target cells, in particular for gene therapy.

Cationic polymers, complexes associating said cationic polymers with therapeutically active substances comprising at least a negative charge, in particular nucleic acids, and their use in gene therapy

Peptide family designated as xenonins, wherein the representative members can be isolated from the substance secreted from the skin of,and having precious pharmaceutical properties.

Family of peptides known as xenoxins

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Achenheim, France

Hanno V J Kolbe