Roche Diagnostics Operations, Inc.

Roche Diagnositcs Operations, Inc.

F. Hoffmann-la Roche Ag

Hanno Langen

Peter Berndt

Johann Karl

Werner Zolg

Marie-Luise Hagmann

Herbert Andres

Gabriele Pestlin

Carlo S Effenhauser

Michael Tacke

Wolfgang Rollinger

Markus Roessler

Remo Anton Hochstrasser

Alois Rainer

Theresa Kott

Albert Roeder

Stefan Palme

Hans-Joachim Hoeltke

Stefan Evers

A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation elementfor the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in areaof a separation plane. According to the invention it is proposed that the separation elementhas a channel or transfer structurefor the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surfacethat is preferably suitable for mass spectroscopic analyses.

Separation method and device for protein mixtures

The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid binding protein II in said sample. Measurement of cellular retinoic acid binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.

Cellular retinoic acid binding protein II as a marker for breast cancer

The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.

Use of protein ASC as a marker for breast cancer

The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.

Nicotinamide N-methyltransferase as a marker for colorectal cancer

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Steinen, Germany

Hanno Langen