Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Vetmedica Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Nihon Nohyaku Co., Ltd.

Boehringer Ingelheim Animal Health USA Inc.

Hannes Fiepko Koolman

Martin Thomas Fleck

Bart Herlé

Gerald Juergen Roth

Cédrickx Godbout

Christian Andreas Kuttruff

Alan Long

Domnic Martyres

Tom Bretschneider

Hyoung Ik Lee

Ikki Yonemura

Thomas Martin Kirrane, Jr

Robin Meier

Julien Gagnepain

Hyoung Lee

Thomas Martin Kirrane Jr

The present invention relates to cyclopropyl-(hetero)aryl substituted ethylsulphonyl-pyridine derivatives of formula (1) wherein the variables are as defined in the description and in the claims, which can be used as antiparasitic agents for the treatment, prevention and/or control of parasitic infections and/or infestations in animals.

Cyclopropyl-(hetero)aryl-substituted ethylsulphonyl-pyridine derivatives

The present invention relates to N-methyl, N-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IFF) or systemic sclerosis (SSc). The present description discloses the preparation of exemplary compounds (e.g. pages 37 to 45; examples 1.1 to 1.13) as well as relevant biological data thereof (e.g. pages 12 to 17, tables 1 to 9). An exemplary compound is e.g. 1-[4-(4-{1-[(6-{[6-(trifluoromethyl) pyridin-3-yl]methoxy}pyridazin-3-yl)amino]cyclopropyl}-phenyl) piperazin-1-yl]ethan-1-one (example 1.1).

N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as Autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases

The present invention encompasses compounds of the formula I which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Heteroaromatic compounds as Vanin inhibitors

This invention provides for compounds of the formula: wherein the variables are defined herein, or salt thereof, compositions comprising these compounds, and method for the treatment, control or prevention of a parasitic infestation or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.

Anthelmintic heterocyclic compounds

A compound of formula (I), (IA) or formula (II) or a composition comprising the compound of formula (I), (IA) or formula (II) in association with a veterinarily acceptable carrier are described. A method of controlling helminths using same is described.

Anthelminthic heterocyclic compounds

Heteroaromatic compounds as vanin inhibitors

This invention provides for compounds of the formula:

Substituted pyrrolo[1,2-b]pyridazines as anthelmintics

This invention provides for compounds of the formula: wherein the variables are defined herein, or a stereoisomer, tautomer, N-oxide, hydrate, solvate, or salt thereof, compositions comprising these compounds, and method for the treatment, control or prevention of a parasitic infestation or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.

Anthelmintic aza-benzothiophene and aza-benzofuran compounds

The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by autotaxin.

N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators

The present invention relates to novel pyridazines of the below formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by autotaxin: 

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Biberach an der Riss, Germany

Hannes Fiepko Koolman