Duke University

Hanne Gr&oslash;n

Salvatore Pizzo

Activation of &agr; -macroglobulin (&agr; M) with a nucleophilic compound followed by incubation of the activated &agr; M at elevated temperature with a biomolecule results in covalent incorporation of the intact biomolecule into the &agr; M molecule, without the use of proteinases. The thus-formed structurally defined and stable complex may be used as an antigen for stimulating the immune response, for example, in the form of a vaccine. Enhanced antigen presentation of a particular biomolecule is provided, especially for those that are poorly immunogenic; reduction of the immunodominance of particular epitopes is also provided.

Growing community of inventors

Chapel Hill, NC, United States of America

Hanne Grøn

Growing community of inventors

Chapel Hill, NC, United States of America

Hanne Gr&oslash;n

Hanne Grøn