Inari Agriculture Technology, Inc.

Hannah Pham

Yajie Niu

Erik William Clement

Michael Andreas Kock

Adam Patrick Joyce

Systems, methods, and compositions for providing improvements in plant gene-editing efficiency are provided.

Methods for improved plant gene-editing

Compounds and related reagents, systems, methods, and compositions for increasing the frequency of homology directed repair (HDR) of target genomic sites with genome editing molecules are provided.

Homology dependent repair genome editing

Systems, methods, and compositions that provide for increased frequencies of plant gene editing in comparison to controls are provided herein. Also disclosed are compositions that provide for editing target genes in plant cells. Systems for modification of a plant genome and/or target plant gene are provided. Methods for modifying a plant cell genome or a target plant gene in a plant cell genome are also provided. Compositions, plant cell cultures, and/or reaction mixtures comprising plant cells, certain agents, and gene editing molecules are also provided herein.

Plant gene editing systems, methods, and compositions

This disclosure provides compositions that include a polynucleotide including or encoding a Cas12a tracrRNA, and methods for their use in sequence-specific genome editing, especially of eukaryotic genomic sequences. In particular, this disclosure provides Cas12a tracrRNA-containing compositions and methods for their use in Cas12a-mediated editing of a target sequence, wherein the editing efficiency is increased in comparison to controls lacking the Cas12a tracrRNA.

Growing community of inventors

Somerville, MA, United States of America

Hannah Pham