Bristol-myers Squibb Compnay

Maze Therapeutics, Inc.

Hannah L Powers

David John Morgans, Jr

Walter Won

Kevin T Mellem

Patrick Sang Tae Lee

Christopher Joseph Sinz

Thomas J Cummins

Scott Arne Johnson

Giorgio Tamo

Disclosed herein are compounds and methods for the prevention and/or treatment of hemoglobinopathies. Also provided herein are such compounds for use in such methods. Also disclosed herein are pharmaceutical compositions comprising such compounds for use in such methods of preventing or treating hemoglobinopathies.

Compounds and their use for treatment of hemoglobinopathies

Provided herein are compounds of formula (I'): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y, Y, L, L, X, X, X, X, X, Q, R, R, R, R, and Rare as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (I&#x2032;). Also provided herein are methods of inhibiting GYS1 and methods of treating a GYS1-mediated disease, disorder, or condition in an individual in need thereof.

Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof

Growing community of inventors

San Diego, CA, United States of America

Hannah L Powers