Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Hannah Jörissen

Frank Wunder

Tobias Marquardt

Simone Greven

Andreas Wilmen

Jan Tebbe

Christoph Mahlert

Thomas Mondritzki

Ernst Weber

Damian Brockschnieder

Ilka Mathar

Lucas Hudson Hofmeister

Claudia Noack

Kirsten Leineweber

Anke Mayer-bartschmid

Stuart Walsh

Marcel Geertz

Nina Alexandra Scheerer

The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Nils), an Atrial Natriuretic Peptide (ANP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of said at least one CDR region is replaced by said at least one heterologous amino acid sequence incorporated therein. The present invention further relates to such antibody or fragment thereof for use in a method for treatment, a composition comprising such antibody or fragment thereof, a nucleic acid or a mixture of nucleic acids encoding such antibody or fragment thereof, a host cell comprising such nucleic acid or such mixture of nucleic acids and to a process for producing such antibody or fragment thereof.

Atrial natriuretic peptide engrafted antibodies

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Heiligenhaus, Germany

Hannah Jörissen