Chiroscience, Ltd.

Darwin Discovery Limited

Hannah Jayne Kendall

John Gary Montana

Hazel Joan Dyke

Alan Findlay Haughan

Christopher Lowe

Verity Margaret Sabin

George Martin Buckley

Andrew Sharpe

Richard John Davenport

Andrew Douglas Baxter

Steven Colin Beasley

Marianna Dilani Richard

David Thomas Manallack

Karen Ann Runcie

Robert James Maxey

Catherine Louise Picken

Hazel John Dyke

Heterocyclic compounds and their therapeutic use

Compounds that are inhibitors of phosphodiesterase and have therapeutic utility, are of formula (i)

Benzothiazole compounds and their therapeutic use

1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumour Necrosis Factor activity. The compounds of the invention have the general formula (I): ##STR1## The compounds of the invention encompassed by formula (I) include enantiomers, diastereoisomers and mixtures, including racemic mixtures.

Quinolones and their therapeutic use

The subject invention concerns novel compounds of the general formula (i) ##STR1## that are useful in treating disease states, such as those states associated with proteins that mediate cellular activity. The compounds of the subject invention can be used, for example, to inhibit tumor necrosis factor and/or phosphodiesterase IV, The subject invention also concerns methods for treating disease states using the compounds of the invention.

Quinoline carboxanides and their therapeutic use

Benzofuran carboxides and sulphonamides have therapeutic utility, e.g. in the treatment of inflammation and asthma, by virtue of their ability to inhibit phosphodiesterases and tumor necrosis factor.

Benzofuran sulphonanmides

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Cambridge, United Kingdom

Hannah Jayne Kendall