Massachusetts Institute of Technology

Hannah Iaccarino

Li-Huei Tsai

Emery Neal Brown

Chinnakkaruppan Adaikkan

Anthony James Martorell

A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

Methods and devices for providing a stimulus to a subject to induce gamma oscillations

The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-&#x3b2; (A&#x3b2;) peptide, C-terminal fragment-&#x3b2; (&#x3b2;-CTF), &#x3b2;-secretase (BACE1), &#x3b3;-secretase, neuroinflammation, and/or dementia (e.g., Alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 Hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (FS-PV) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.

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Somerville, MA, United States of America

Hannah Iaccarino