Merck Sharp + Dohme Corp.

Hannah D G F Lehman

Mark E Layton

Michael J Kelly, Iii

Joseph E Pero

Michael A Rossi

Dansu Li

Lianyun Zhao

Scott E Wolkenberg

James J Mulhearn

Kevin F Gilbert

Pablo De Leon

Michael J Iii Kelly

Disclosed are compounds of Formula A: Formula A, or a salt thereof, wherein 'Het', R, and Rare defined herein, which have properties for blocking Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating neuropathic pain disorders using the same. 

Benzoxazolinone compounds with selective activity in voltage-gated sodium channels

Disclosed are compounds of Formula Aand Formula A: wherein 'Heteroaryl-1', R, R, R, and Rare defined herein, which novel compounds have properties for blocking Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formulae Aand Aor their salts, and methods of treating neuropathic pain disorders using the same. 

N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels

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Boyertown, PA, United States of America

Hannah D G F Lehman