3m Innovative Properties Company

Solventum Intellectual Properties Company

Hannah C Cohen

Amanda Catherine Engler

Joel D Oxman

Yizhong Wang

Jie Yang

Katie Fraass Wlaschin

Tiffany T Ton

Tao Gong

Ranjani V Parthasarathy

Matthew T Scholz

George W Griesgraber

Jana Ninkovic

Haoming Rong

Audrey A Sherman

William Bedingham

Ramesh C Kumar

Richard G Hansen

Richard Paul Rusin

Naimul Karim

Nicholas Ransom Powley

Douglas A Hanggi

Semra Colak Atan

Carl A Laskowski

Petra L Kohler Riedi

Timothy M Gillard

Roxanne A Boehmer

Saurabh Batra

Korey W Karls

Michael J Vostal

Paul R Klaiber

Jodi L Connell

Joseph J Stoffel

James Patrick DiZio

Joseph A Dunbar

Catherine D Heapy

Colby W Dotseth

Max A Kruziki

Petra L Kohler Reidi

Dale J Case

David Duane Johnson

Michelle H Stevens

Ingo R Haeberlein

Phosphate-containing copolymers, medical compositions containing the phosphate-containing copolymers, and methods of suppressing microbial virulence are provided. By suppressing virulence, administration and/or application of the medical compositions can be used to prevent, mitigate, or treat a microbial infection. The phosphate-containing copolymers are prepared by phosphorylating either a random copolymer or a random copolymeric block that contains monomeric units of propylene oxide and glycidol.

Phosphate-containing copolymers for virulence suppression

Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

N-1 branched cycloalkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods

Articles that include from 70 wt-% to 99 wt-% of one or more plant based oil that is solid at 25° C., the weight percent based on the total weight of the article; and from 0.5 wt-% to 10 wt-% of fumed silica, the weight percent based on the total weight of the article. Methods of use of the articles are also included.

Oral articles and methods of use

Compositions that include: from 5 wt-% to 70 wt-% of one or more plant based oils based on the total weight of the composition; from 35 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; not greater than 7.5 wt-% of one or more surfactants based on the total weight of the composition; and not greater than 3 wt-% of a viscosity modifier of, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.

Oral compositions and methods of use

A method of making a nonwoven fiber web comprises: providing a melt-blown nonwoven fiber web comprising bonded primary fibers having an average fiber diameter of 2 to 100 microns, wherein the primary fibers comprise a copolymer comprising divalent hydroxyethylene monomer units and divalent dihydroxybutylene monomer units; opening at least a portion of the melt-blown nonwoven fiber web to provide loose primary fibers; combining the loose primary fibers with secondary fibers; and forming a secondary nonwoven fiber web comprising the primary fibers and secondary fibers. A fiber web preparable according to the method and a multicomponent fiber including a first phase comprising a copolymer comprising divalent hydroxyethylene monomer units and divalent dihydroxybutylene monomer units and a second phase comprising a non-biodegradable polymer.

Method of making a nonwoven fiber web, nonwoven fiber web, and multi-component fiber

Imidazo[4,5-c]quinoline compounds of Formula (I) having a substituent that is attached at the N−1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

Compositions that include from 0.1 wt-% to 8 wt-% of one or more compounds of formula (I) based on the total weight of the compositionHOCH&#x2014;(CHOH)&#x2014;CHNRR&#x2003;&#x2003;(I)wherein Rand Rare independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R, and SOR; with Rand Rbeing independently selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group; wherein n is an integer from about 2 to about 5; from 5 wt-% to 95 wt-% of one or more plant based oils based on the total weight of the composition; from 5 wt-% to 80 wt-% water based on the total weight of the composition and from 0.01 wt-% to 1 wt-% of one or more nonionic aromatic phenolic preservatives based on the total weight of the composition wherein the composition has a pH from 4.5 to 9.5, the composition is an emulsion, and the composition is edible.

Compositions that include: from 5 wt-% to 30 wt-% of one or more plant based oils based on the total weight of the composition; from 70 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; from 0.1 wt-% to 5 wt-% of one or more surfactants based on the total weight of the composition; and from 0.05 wt-% to 3 wt-% of a viscosity modifier, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.

A copolymer composition that includes a silicone copolymer, methods of making the composition, and articles that include the composition, wherein the copolymer composition includes a silicone copolymer having a backbone composition that includes: silicone segments in an amount of 5 wt-% to 40 wt-%, based on the total weight of the silicone copolymer; hydrophilic segments in an amount of 40 wt-% to 75 wt-%, based on the total weight of the silicone copolymer; and reinforcing segments in an amount of 5 wt-% to 30 wt-%, based on the total weight of the silicone copolymer, wherein the reinforcing segments are derived from the reaction of one or more chain extenders with one or more multi-functional isocyanates, multi-functional carboxylic acids, multi-functional anhydrides, multi-functional esters, and/or multi-functional acid halides; wherein the silicone segments, hydrophilic segments, and reinforcing segments are connected through urea, urethane, amide, and/or oxamide linkages; wherein the hydrophilic segments and the reinforcing segments are present in a weight ratio of 1.8:1 to 8:1; and the hydrophilic segments and the silicone segments are present in a weight ratio of 1.3:1 to 4.5:1.

Silicone copolymers, methods of making, and articles

Shapeable articles, kits including one or more of the shapeable articles, and methods of making and/or using the shapeable articles. The shapeable articles include a shapeable member that can be shaped or manipulated into three-dimensional shapes without the use of tools and hold those shapes after removal of the force required to achieve the shape. The shapeable articles could have a variety of uses including use as surgical retractors to move and/or restrain non-target tissue and/or organs to improve access to the target tissue and/or organs.

Shapeable articles and methods of making and using the same

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Saint Paul, MN, United States of America

Hannah C Cohen