Amgen Inc.

Cytokinetics, Inc.

Massachusetts Institute of Technology

The Trustees of Boston College

Hanmo Zhang

Bradley Paul Morgan

Chihyuan Chuang

Luke W Ashcraft

Michael G Johnson

Felix Gonzalez Lopez De Turiso

Scott E Collibee

Alan C Cheng

Russell Graceffa

Alessandro Boezio

Mikkel V Debenedetto

Antonio Romero

David Joseph St Jean, Jr

Richard Vargas

David C Moebius

Joshua Payette

John R Butler

Aroop Chandra

Justin Malinowski

John Yeoman

Vincent DiMassa

Richard Royce Schrock

Amir H Hoveyda

Ming Joo Koh

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Bisamide sarcomere activating compounds and uses thereof

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. 

Bisamide sarcomere activating compounds and uses therof

The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and Z-selectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and E-selectivity. In some embodiments, provided technologies are particularly useful for preparing alkenyl fluorides. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-a. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-b.

Metathesis catalysts and methods thereof

Growing community of inventors

Chestnut Hill, MA, United States of America

Hanmo Zhang