The University of Texas System

Non-invasive Technology Inc.

Other

Hanli Liu

Britton Chance

Jeffrey A Cadeddu

Cole A Giller

Vikrant Sharma

Disha L Peswani

Venkaiah C Kavuri

A diagnostic imaging device includes a probe that uses both an ultrasound transducer and frequency-domain diffuse optical imaging (FD-DOI) to assist with locating and diagnosing sub-tissue anomalies. According to one aspect, the diagnostic imaging device relates to a clip-on cap that can be utilized with existing ultrasound transducers. The diagnostic imaging device described herein can be utilized for image-guided needle biopsy to regions where prostate tissues are highly suspicious for high-grade cancer, as well as for image guided interventions, such as cryotherapy, photodynamic therapy, and brachytherapy for early-stage or localized prostate cancer.

Methods and systems for detecting sub-tissue anomalies

The present invention includes an apparatus, system and method for detection of tissues, e.g., a cancer, by optical biopsy comprising: a motorized computer-controlled probe holder; a needle-like probe connected to and controlled by the motorized computer-controlled probe holder, the probe comprising an optical and an ultrasound detector; and one or more detector units capable of a broadband light reflectance spectroscopy, an auto fluorescence lifetime measurement, and auto fluorescence spectroscopy measurement.

Optically guided needle biopsy system using multi-modal spectroscopy in combination with a transrectal ultrasound probe

The present invention includes using optical spectroscopy as an innovative technique for ex-vivo demonstration of renal and prostate tumors. The apparatus and methods disclosed herein demonstrate the ability of optical spectroscopy to reliably differentiate tumor from normal tissue in renal specimens.

Optical methods to intraoperatively detect positive prostate and kidney cancer margins

This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system () containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes, generally sugars (mannitol, fructose, sucrose, glucose, sorbitol), alcohols (methanol, ethanol, propanediol), and electrolytes (sodium, potassium, magnesium, calcium, and chloride ions).

Examination of scattering properties of biological tissue

Method and apparatus for probe localization in brain matter. A method is disclosed for determining the insertion point for an object at a desired location within tissue of varying types. The parameters of tissue are first measured at an entry point into the tissue from exterior thereof. The parameters of the tissue are then measured periodically along a line extending from the entry point and moving away therefrom. A determination is then made if at least one boundary between tissue types has occurred during the measurement process. The measurements along the line are then compared to a predetermined map of the tissue boundaries. Thereafter, a point on the map is then selected corresponding to the desired location within the tissue when the measured parameters indicate that the measurements are taking place in proximity thereto.

Method and apparatus for probe localization in brain matter

This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system ( ) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light ( ), the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more as characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes, generally sugars (mannitol, fructose, sucrose, glucose, sorbitol), alcohols (methanol, ethanol, propanediol), and electrolytes (sodium, potassium, magnesium, calcium, and chloride ions).

Examination of biological tissue by monitoring one or more solutes

A scheme for monitoring one or more solutes in a biological system comprising the steps of: delivering light into a biological system containing one or more solutes, the light having a wavelength selected to be in a range wherein at least one of the one or more solutes is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor a concentration of one or more of the solutes in the biological system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes, generally sugars (mannitol, fructose, sucrose, glucose), alcohols (methanol and propanediol), and electrolytes (sodium and potassium chloride).

Growing community of inventors

Arlington, TX, United States of America

Hanli Liu