Uxn Co., Ltd.

Seoul National University

Hankil Boo

Rae Kyu Chang

Sejin Park

Joungmin Lee

Sunyoung Lee

Taek Dong Chung

Hee-Chan Kim

This disclosure relates to an apparatus for glucose-sensing that address interference of ascorbic acid and acetaminophen. The apparatus includes a first electrode capable of oxidizing glucose and at least one of ascorbic acid and acetaminophen. The apparatus further includes a second electrode capable of oxidizing at least one of ascorbic acid and acetaminophen but not capable of oxidizing glucose. The first electrode includes a deposit of irregularly shaped bodies that are formed of numerous nanoparticles having a generally oval or spherical shape with a length ranging between about 2 nm and about 5 nm.

Glucose sensor apparatus addressing interference of ascorbic acid and acetaminophen

This disclosure relates to a glucose-sensing electrode including a nanoporous layer on an electrically conductive surface. The nanoporous layer includes a three-dimensional interconnected network of irregularly shaped bodies that are formed of numerous nanoparticles having a generally oval or spherical shape with a length ranging between about 2 nm and about 5 nm. Inside the three-dimensional interconnected network of irregularly shaped bodies, at least part of the nanoparticles are adjacent to each other without an intervening nanoparticle therebetween and apart from each other to define interparticular nanopores therebetween, wherein at least part of the interparticular nanopores inside the three-dimensional interconnected network of irregularly shaped bodies are in a size ranging between about 0.5 nm and about 3 nm. The nanoporous layer further comprises a three-dimensional interconnected network of irregularly shaped spaces that is geometrically complementary to the three-dimensional interconnected network of irregularly shaped bodies. The glucose-sensing electrode does not comprise a glucose-specific enzyme.

Glucose-sensing electrode and device with nanoporous layer

This disclosure relates to an apparatus for glucose-sensing that address interference of ascorbic acid and acetaminophen. The apparatus includes a first electrode capable of oxidizing glucose and at least one of ascorbic acid and acetaminophen. The apparatus further includes a second electrode capable of oxidizing at least one of ascorbic acid and acetaminophen but not capable of oxidizing glucose. The first electrode includes a deposit of irregularly shaped bodies that are formed of numerous nanoparticles having a generally oval or spherical shape with a length ranging between about 2 nm and about 5 nm. The deposit is substantially free of a surfactant. If any surfactant is contained in the deposit, the surfactant is in an amount smaller than 0.5 parts by weight with reference to 100 parts by weight of the deposit. The first electrode does not include a glucose-specific enzyme.

This application features a method of forming a nanoporous layer. The method includes steps of dispensing on a substrate a colloid composition comprising a liquid and a number of nanoparticle clusters, and subjecting the dispensed colloid composition to drying to form the nanoporous layer over the substrate. The nanoporous layer includes nanoparticles deposited to form a three dimensional network of irregularly shaped bodies. The nanoporous layer also includes a three dimensional network of irregularly shaped spaces that are not occupied by the three dimensional network of irregularly shaped bodies.

Method of making nanoparticle colloid and nanoporous layer

This application features a method of forming a nanoporous layer. The method includes steps of reducing metal ions in a reverse micelle phase composition to form nanoparticles, removing surfactant from the composition to form clusters of the nanoparticles, dispensing the composition including the nanoparticle clusters dispersed in a liquid on a substrate, and drying to form the nanoporous layer. The nanoporous layer includes nanoparticles deposited to form a three dimensional network of irregularly shaped bodies. The nanoporous layer also includes a three dimensional network of intercluster spaces that are not occupied by the three dimensional network of irregularly shaped bodies.

This disclosure relates to a glucose-sensing electrode including a nanoporous metal layer and an electrolyte ion-blocking layer formed over the nanoporous metal layer. The nanoporous metal layer is capable of oxidizing both glucose and maltose without an enzyme specific to glucose in the glucose-sensing electrode. The electrolyte ion-blocking layer is configured to inhibit Na, K, Ca, Cl, POand COfrom diffusing toward the nanoporous metal layer such that there is a substantial discontinuity of a combined concentration of Na, K, Ca, Cl, POand CObetween over and below the electrolyte ion-blocking layer.

Non-enzymatic glucose-sensing device with nanoporous structure and conditioning of the nanoporous structure

This disclosure relates to a glucose-sensing electrode including a nanoporous metal layer and a maltose-blocking layer formed over the nanoporous metal layer. The nanoporous metal layer is capable of oxidizing both glucose and maltose without an enzyme specific to glucose or maltose in the glucose-sensing electrode. The maltose-blocking layer has porosity that permits glucose to pass therethrough and inhibits maltose from passing therethrough toward the nanoporous metal layer.

Glucose-sensing device with maltose blocking layer

This disclosure relates to a nanoporous composition including a number of clusters of nanoparticles dispersed in a liquid, a nanoporous layer formed of the nanoporous composition, a glucose-oxidation electrode including the nanoporous layer, and a glucose-sensing device and system including the glucose-oxidation electrode. This disclosure also relates to a method of making the nanoporous composition, the nanoporous layer, the glucose-oxidation electrode and the glucose-sensing device and system. Further, this disclosure also relates to devices, systems and methods for continuous glucose monitoring (CGM) and blood glucose monitoring (BGM).

Method of making a colloid and nanoporous layer

A method for the fabrication of a mesoporous metal electrode in a non-liquid crystalline phase was tested. Specifically, there was tested the efficacy of the method for the fabrication of a mesoporous metal electrode which comprises forming the mesoporous metal electrode on a substrate by chemical or electrochemical reduction of a mixture comprising a solvent, a structure-directing agent, and a source of a metal, characterized in that the mixture is maintained in a non-liquid crystal phase. Furthermore, the usefulness of the mesoporous metal electrode thus prepared from the non-liquid crystalline phase was also tested. The mesoporous metal electrode prepared from the non-liquid crystalline phase had a large surface area, and a roughness factor thereof was controlled by charges passed during electroplating. The method made it possible to fabricate the mesoporous metal electrode in the non-liquid crystalline phase, even more flexible than a liquid crystalline phase. The mesoporous metal electrode prepared by the method had randomly distributed mesopores on the surface thereof and retained a large roughness factor. The method was found to be a good alternative to the conventional fabrication of porous platinum films in the liquid crystalline phase. Furthermore, the method was found to be suitably applicable to automatic processes, because the mesoporous metal electrode was prepared in the highly flexible non-liquid crystalline phase. Recovery and recycling of raw materials were also improved. The mesoporous metal electrode prepared by the method can be suitably used for the detection of glucose and proton, and as a cathode or an anode of fuel cells.

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Seoul, South Korea

Hankil Boo