Avidity Biosciences, Inc.

Hanhua Huang

Rob Burke

Andrew John Geall

Venkata Ramana Doppalapudi

Michael Caramian Cochran

Arthur A Levin

Disclosed herein are molecules and pharmaceutical compositions that induce an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that induces an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion.

Nucleic acid-polypeptide compositions and methods of inducing exon skipping

Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against EGFR. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against EGFR.

EGFR nucleic acids and uses thereof

Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against KRAS. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against KRAS.

KRAS nucleic acids and uses thereof

Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against CTNNB1. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against CTNNB1.

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San Diego, CA, United States of America

Hanhua Huang