Korea Research Institute of Bioscience and Biotechnology

Hang Sub Kim

Jung Joon Lee

Jeong-Hyung Lee

Young Ho Kim

Young-Soo Hong

Young Soo Hong

Yun Joo Park

Jeong Bum Nam

Dong Hwan Shon

The disclosure concerns an extract ofand its use. More particularly, it concerns the extract ofcomprising 1) the extract ofextracted from water, 2) among the water extract, the extract ofonly containing ethanol insoluble part obtained by precipitating ethanol, 3) among the ethanol insoluble part, the extract ofcontaining polysaccaride with a molecular weight larger than range of 12,000&#x2dc;14,000, or 4) among the ethanol insoluble part, the extract ofcontaining polysaccaride with a molecular weight larger than 100,000, which is respectively obtained from the root or stem ofThe extract of the present invention shows a high inhibitory activity against hepatitis and protects the liver, and thus, can be used for the treatment or prevention of hepatitis, or as a liver protective drug.

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Disclosed are a novel compound represented by the following chemical formula (1), useful for the prophylaxis and treatment of angiogenic diseases, its production, and a novel microorganism producing the same. Aspergillus sp. Y80118 isolated from soil was found to produce 7,8-dihydro-1,7-dihydroxy-3-hydroxymethyl-xanthenone-8-carboxylic acid methylester which inhibits VEGF-induced proliferation of HUVEC, angiogenesis in CAM assay, and tumor growth. The novel compound can be effectively used for the medical treatment of anigiogenic diseases, including cancers, rheumatoid arthritis, and diabetic retinopathy.

7,8-dihydro-xanthenone-8-carboxylic acid derivative and novel microbe producing the same

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Taejeon-si, South Korea

Hang Sub Kim