University of Colorado

University of Pennsylvania

Hang Hubert Yin

Qiuping Peng

Songguo Xue

Kui Cheng

Yanxin Hu

William F DeGrado

Tad H Koch

Benjamin L Barthel

Linda R Watkins

Joanna S Slusky

Alla Balabanova

Shuting Zhang

Zhenyi Hu

Ryo Tamura

Pipette

Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.

Toll-like receptor 8 (TLR8) specific antagonists and methods of making and uses thereof

The present invention includes compounds of the class anthracycline that have been modified to include photo-activated prodrug anthracycline compounds that are useful in the treatment of cancer. One example composition of the invention may include photodoxazolidine which may be synthesized in two steps from 4,5-dimethoxy-2-nitrobenzyl alcohol and doxazolidine. In this embodiment commercial 4,5-dimethoxyl-2-nitrobenzyl alcohol reacts with p-nitrophenylchloroformate to give the p-nitrophenyl carbonate of the benzyl alcohol derivative. The p-nitrophenyl carbonate is then reacted with doxazolidine to give the exemplary photodoxazolidine composition.

Anthracycline prodrugs and methods of making and using the same

Provided are compounds, compositions and methods for treating Toll-like receptor 1/2 complex (TLRI/2) related inflammatory disorders. Small molecules, based on the benzotropolone scaffold, capable of influencing downstream signaling are disclosed as well as methods of making and modifying these molecules. Also provided are methods for treating a subject for a clinical condition associated with Toll-like receptor complex 1/2 activation, comprising administering to the subject an effective amount of a benzotropolone compound.

Antagonists of the toll-like receptor 1/2 complex

The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula: compositions comprising and methods for using the same, where n, Ar, Ar, X, X, X, Z, and Zare those defined herein.

Modulators of TLR3/dsRNA complex and uses thereof

The present invention provides a compound of the formula: where n, m, X, X, X, X, R, Rand Rare those defined herein. Some aspects of the invention also provides methods for using these compounds and compositions comprising the same.

Toll-like receptor modulators and uses thereof

Polypeptides which bind to the helical transmembrane region of membrane proteins are disclosed, as are methods for the design of polypeptides that bind to the transmembrane region of membrane proteins. Also provided are methods for the use of the disclosed polypeptides in various applications, as well as products made through the practice of the instant methods.

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Boulder, CO, United States of America

Hang Hubert Yin