Intel Corporation

Bgi Shenzhen

Affymetrix, Inc.

Sigma-aldrich Co. LLC

Mgi Tech Co., Ltd.

Life Technologies Corporation

Applied Biosystems, LLC

Genoimmune Therapeutics Co., Ltd.

Complete Genomics, Inc.

Bgi-shenzhen Co., Limited

Mgi Holdings Co., Limited

Handong Li

Radoje Drmanac

Snezana Drmanac

Narayan Sundararajan

John G Dapron

Naibo Yang

William Karl Kappel

Wei W Wang

Hernan Adolfo Castro

Glenn H McGall

Xing Su

Xun Xu

Brandon Barnett

Gordon D Holt

Robert G Eason

Noureddine Tayebi

Richard J Mehigh

Bo Li

Matthew J Callow

Yong Hou

Maxim G Brevnov

Shuntao Luo

Aldrich Lau

Xiumei Lin

Ting An

Kevin Hacker

Zhen Cheng

Chengchi Chao

Lingling Peng

Scott Gablenz

Leon Eckhardt

Venkatappa Viswanatha

Steven Menchen

Wei Zhang

Hui Fu Jiang

Aldrich N K Lau

Wenwei Zhang

Kai Wu

Oguz Hasan Elibol

Anthony Dale Barone

Grace M Credo

Meng Taing

Christina E Inman

Jingwu Zhang

Narayanan Sundararajan

Chongjun Xu

Chunyu Geng

Jonathan S Daniels

He Zhang

Khai Luong

Andrea Cuppoletti

Kristian Michael Scaboo

Geng Liu

Guanglei Li

Jing Yu

Dongli Li

Eric Harness

Sarah M Ngola

Shaohua Xiang

Y Tom Tang

Hui Jiang

Yan Chen

Guangyi Fan

Kailong Ma

Madoo Varma

Chongming Jiang

Si Qiu

Drew Hall

Vankatappa Viswanatha

Yongwei Zhang

Quanxin Yun

Acridinium ester-containing compounds are provided herein. Also provided herein are chemiluminescence-based one-color sequencing methods and methods of using the acridinium ester-containing compounds in chemiluminescence-based one-color sequencing.

Acridinium ester-containing compounds and methods of using the same for chemiluminescence-based one-color sequencing

Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.

Reversibly blocked nucleoside analogues and their use

The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.

Nucleic acid sequencing using affinity reagents

Provided are a tumour antigen polypeptide having the amino acid sequence as shown in SEQ ID NO: 2 or a variant thereof; a nucleic acid encoding same; a nucleic acid construct, an expression vector, and a host cell comprising the encoding nucleic acid; and an antigen presenting cell presenting the tumour antigen polypeptide on the cell surface and an immune effector cell thereof. Also provided is the use of the polypeptide, nucleic acid, antigen presenting cell or immune effector cell in the diagnosis, prevention and treatment of cancers.

Col14A1-derived tumor antigen polypeptide and use thereof

Provided are a tumor antigen polypeptide having the amino acid sequence as shown in SEQ ID NO: 2 or a variant thereof; a nucleic acid encoding the same; a nucleic acid construct, an expression vector, and a host cell containing the encoding nucleic acid; and an antigen presenting cell presenting the tumor antigen polypeptide on the cell surface and an immune effector cell thereof. Also provided is the use of the polypeptide, nucleic acid, antigen presenting cell or immune effector cell in the diagnosis, prevention and treatment of cancers.

CACNA1H-derived tumor antigen polypeptide and use thereof

Improved single molecule sequencing methods, compositions, and devices, are provided. In a first aspect, the present invention provides a multi-pass method of sequencing a target sequence using nanopore sequencing, the method comprising: i) providing a non-naturally occurring concatemer nucleic acid molecule comprising a plurality of copies of the target sequence; ii) nanopore sequencing at least three copies of the target sequence in the concatemer, thereby obtaining a multi-pass sequence dataset, wherein the multi-pass sequence dataset comprises target sequence datasets for the at least three copies of the target sequence; and iii) using the multi-pass sequence dataset to determine the target sequence.

Multi-pass sequencing

Novel fluorescent nucleotide analogs are provided herein. Also provided herein are methods of using the nucleotide analogs in sequencing-by-synthesis and signal confinement methods.

Signal confinement sequencing (SCS) and nucleotide analogues for signal confinement sequencing

Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.

Highly selective coated-electrode nanogap transducers for the detection of redox molecules

Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.

High throughput biochemical detection using single molecule fingerprinting arrays

A method for the introduction of a labeling structure such as fluorescent molecules or a Raman tag to a compound is described. Imidazole functionalized resins or polymers are used to selectively immobilize phosphocompounds without protecting the carboxylic groups is described. Relying on the pKa difference between amines and hydrazides and carrying out the reaction in a slightly acidic buffer, all of the amines are protected by protonation while the hydrazides react with the phosphate imidazolide to form a phosphoramidate bond.

Method for the selective enrichment and labeling of phosphorproteins

Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.

Magnetic beads having surface glycoconjugates and use thereof

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San Jose, CA, United States of America

Handong Li