Biotillion, LLC

Coldtrack, LLC

Hananel Davidowitz

Theodore N Altman

Thomas Coradetti

Ke Wang

Jeremy Basch

Zhengyan Zhai

Ron Or

Yair Talmi

Ilya Kovnatsky

Roni Or

A technique for tracking, for example, the temperature of one or more sample vials containing biological material stored in a low-temperature shipping vessel. Each sample vial has vial electronics that senses temperature and transmits temperature data to the reader head of a reader device, which has a controller that is not at the low temperature. In some implementations, the shipping vessel has a cap with a recess that houses the controller and a hollow plug that houses a cable that connects the controller to the reader head that is located in the vessel's cold interior sufficiently close to the sample vial to enable interaction with the vial electronics. In some implementations, the reader head transmits electrical power to the vial electronics. By tracking the temperature of individual sample vials rather than the temperature of the vessel interior, more-relevant temperature data is available.

Techniques for tracking physical parameters such as temperature of transported biological materials

A storage system having racks and an outer container that receives the racks, each rack receiving a plurality of sample boxes, each box having a wireless ID tag. In certain embodiments, the storage system has reader electronics external to and distinct from the racks and that directly read the wireless ID tag of each box in at least one rack without relying on any reader electronics of any rack. In other embodiments, each rack has a set of rack reader electronics that read the wireless ID tag of each box in at least one rack, and the storage system has at least one removable reader access device removably connectable to the set of rack reader electronics of a rack in order to transmit the ID number of the wireless ID tag of each box in the rack outside of the outer container.

Storage system for biological samples and the like

In one embodiment, a freezer system has one or more shelves, each shelf has shelf electronics and can receive one or more racks, each rack has rack electronics and one or more cells for receiving one or more boxes of samples, each box has one or more RFID tags. Freezer electronics communicate with the outside world and with each set of shelf electronics. Each set of rack electronics communicates wirelessly with the corresponding set of shelf electronics and with the corresponding box RFID tags. Power for the rack electronics is derived from wireless signals from the shelf electronics. The freezer system can detect the presence of racks on shelves and boxes on racks to track the location and the orientation of each received box.

Tracking of sample boxes using energy harvesting

A storage system for storing samples, such as frozen biological samples in RFID-tagged vials. The storage system has (i) a storage device having a device antenna and (ii) a plurality of storage components adapted to be stored within the storage device, each storage component having a component circuit. Each storage component is configured to store one or more samples. The storage device is configured to (i) transmit electrical power and downlink data signals wirelessly to each storage component via the device antenna and the corresponding component circuit and to (ii) receive uplink data signals from each storage component wirelessly via the corresponding component circuit and the device antenna such that a control system located outside of the dewar can identify any specified storage component stored within the storage device.

Storage devices for RFID-tracked biological and other samples

A storage system for storing samples, such as frozen biological samples in RFID-tagged vials. The storage system has a plurality of lowest-level containers, such as sample boxes; a plurality of mid-level containers, such as shelves and racks; and a highest-level container, such as a mechanical freezer. Each lowest-level container receives a plurality of samples in a corresponding plurality of storage locations, each mid-level container receives two or more lowest-level containers, and the highest-level container receives the two or more mid-level containers. Each mid-level container and each lowest-level container has a corresponding indicator device. A controller sub-system tracks the locations of samples stored in the storage system. When a desired sample is to be retrieved from the storage system, the controller sub-system activates (a) the indicator device corresponding to the mid-level container containing the desired sample and (b) the indicator device corresponding to the lowest-level container containing the desired sample.

Guided retrieval for RFID-tracked biological and other samples

A box mapper has (i) a frame configured to receive a sample box of RFID-tagged sample vials and (ii) a set of antennae configured to read the vial RFID tags of the sample vials to determine the identity and position of each sample vial in the sample box. In one embodiment, the set of antennae include two mutually orthogonal subsets of biphase digit antennae.

Tracking biological and other samples using RFID tags

RFID tags are affixed to vials used to store samples, such as biological samples stored in liquid nitrogen dewars or mechanical freezers. In one set of embodiments, an RFID tag is inserted into a recess at the bottom of a vial and held in place by an insert that engages with vial structure. In another set of embodiments, the RFID tag is retained in the recess by directly engaging with the vial structure and without using a separate insert. Mechanisms for keeping the insert and/or tag in place include tabs that gouge into the vial material, clips that allow the insert/tag to be inserted, but not removed, and holes in the side wall of the vial recess that receive tabs extending from the insert/tag. Tag-insertion techniques enable tags to be affixed to vials either before or after insertion of the sample, thereby enabling retrofitting of existing sample-storing vials with tags.

In one embodiment, a cold storage system for biological samples has one or more freezers, each freezer having one or racks, each rack receiving one or more boxes, each box receiving one or more sample containers. In addition to the biological sample, each sample container has a unique passive RFID tag. Control electronics in each box energize reader coils to query individual RFID tags. Control electronics in each rack communicate with and provide power to the control electronics of each corresponding box, and control electronics in each freezer communicate with and provide power to the control electronics of each corresponding rack, and a host computer communicates with the control electronics in each freezer. In each instance, communication and power provisioning is implemented using magnetic inductive coupling. The system is able to determine the identity of each sample container in the system and maintain that information in a database.

Hierarchical sample storage system

In one embodiment, an antenna configuration for locating RFID tags has two sets of (mutually orthogonal) elongated reader coils, where each elongated reader coil corresponds to two or more different possible locations of RFID tags, and each possible location is associated with one reader coil in each of the two sets. The identities and locations of RFID tags can be determined by (sequentially) energizing the different sets of reader coils and correlating the recorded responses from RFID tags. In one application, the antenna configuration is used at the box level of a cold storage system for biological samples having one or more freezers, each freezer having one or racks, each rack receiving one or more boxes, each box receiving one or more sample containers, where, in addition to the biological sample, each sample container has a unique passive RFID tag.

Growing community of inventors

Princeton, NJ, United States of America

Hananel Davidowitz