Corning Incorporated

Kuraray Co., Ltd.

Hanaka Mimura

Kaoru Kobayashi

Yoko Ejiri

Satoru Ayano

Kan Chiba

Masaya Hosoda

Provided is a technique that uses an established hepatocyte cell line in a method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 and in a method for evaluating a drug which interacts with a cytokine. The method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 includes: culturing an established hepatocyte cell line by using a culture chamber () including culture rooms (), to thereby form spheroids (); and evaluating the presence or absence of induction or attenuation of the cytochrome P450 after bringing a spheroid-shaped established hepatocyte cell line into contact with a test solution containing the cytokine in the culture chamber for one hour or more and less than 96 hours.

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Chiba, Japan

Hanaka Mimura