University of Delaware

Han Zhang

Joseph M Fox

Yinzhi Fang

Colin Thorpe

Yixin Xie

Xinqiao Jia

Joel Rosenthal

Will Trout

Shuang Liu

A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the other R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl,- or heteroatom-containing groups; 1, 2 wherein the method comprises oxidizing dihydrotetrazine 1 in a reaction medium in the presence of a catalyst and a stoichiometric oxidant. 

Methods for inducing bioorthogonal reactivity

A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiRR, CH, CHOH, and CHR; Ris phenyl or CH; Ris phenyl, CH, (CH)CN, or (CH)OH, wherein n is an integer from 1 to 5; Rand Rare each individually selected from the group consisting of H, OH, and CH; and Z and L are not both SiRR; or b) Z is BocN, L is CH, Ris H, and Ris H; or c) Z is C=0, L is CH, Ris H, and Ris H. 

Trans-cycloheptenes and hetero-trans-cycloheptenes for bioorthogonal coupling

Growing community of inventors

Columbia, MD, United States of America

Han Zhang