William Marsh Rice University

Leland Stanford Junior University

Columbia University

Han Xiao

Carolyn Ruth Bertozzi

Gerard Karsenty

Elliot C Woods

Melissa Gray

Julian Berger

Juan Tang

Provided are conjugates including a targeting moiety that binds to a cell surface molecule of a target cell and a target cell surface-editing enzyme. Also provided are compositions and kits that include the conjugates, as well as methods of using the conjugates. Methods of making conjugates are also provided.

Conjugates for targeted cell surface editing

Cytokine-bisphosphonate conjugates and methods of use thereof in muscle functions.

Cytokine-bisphosphonate conjugates

Exemplary methods, compositions and uses thereof can be provided for preventing, reducing and/or treating loss of muscle function. In particular, e.g., it is possible to administer to a subject a pharmaceutical composition comprising a therapeutically effective amount of an agent that enhances Interleukin-6 (IL) release during exercise, and optionally a pharmaceutically acceptable carrier or excipient.

Methods, compositions and uses thereof for reversing sarcopenia

Disclosed herein are photoactivable fluorophores comprising one or more thiocarbonyl groups as well as conjugates and compositions thereof. The present disclosure also provides methods of preparing photoactivatable fluorophores as well as methods of imaging using the photoactivatable fluorophores, conjugates, and compositions of the present disclosure.

Growing community of inventors

Houston, TX, United States of America

Han Xiao