Industry Academic Cooperation Foundation Hallym University

Han Na Lee

Young Jin Lee

Soon Hee Kim

Chan Hum Park

Ji Ye Kim

Oh Jun Kwon

Ok Joo Lee

Ji Seung Lee

Ji Won Heo

Md Tipu Sultan

Olatunji Abolarin Ajiteru

Jang Min Kim

The present disclosure relates to the composition and process for the production of an ultra-strong, biocompatible, electroconductive, and stretchable hydrogel, which comprises: a step (a) of physical or chemical modification of natural polymers e.g., preparation of silk nanofiber and double methacrylation of gelatin; a step (b) of graphene oxide (GO) carboxylation; a step (c) of carbodiimidation between methacrylated natural polymers of step (a) and carboxylated GO of step (b); and a step (d) of three dimensional (3D) bioprinting of step (c) with/without silk nanofiber. It was found that these steps in this disclosure give rise to a biocompatible hydrogel with high mechanical strength in the range of load-bearing soft tissue such as tendon and heart as opposed to conventional hydrogels.

Photo-curable bioink to fabricate ultra-strong, electroconductive, and biocompatible hydrogel for regenerative medicine

Growing community of inventors

Chuncheon-si, South Korea

Han Na Lee