Technical Institute of Physics and Chemistry, Cas

Beijing Cas Microneedle Technology Ltd.

Ccteg Chinese Institute of Coal Science

Han Liu

Yue Hua Zhang

Jingwen Zhang

Yunhua Gao

Qingjie Qi

Suohui Zhang

Jiamei Chai

Aguo Cheng

A nanonization method for cannabidiol (CBD) includes following steps: the CBD is dissolved in a good solvent to obtain a CBD-good solvent solution, the CBD-good solvent solution is added to aqueous solution of a stabilizer to obtain mixed solution, the mixed solution is ultrasonicated followed by removing the good solvent by rotary evaporation from the mixed solution to obtain a nanosized CBD suspension. The stabilizer includes one or more selected from the group consisting of poloxamer, tween, polyoxyethylene alkyl ether, polyvinyl pyrrolidone, hydroxypropyl methyl cellulose and carboxymethyl chitosan. Particle size of the CBD is reduced in the nanonization method for the CBD through the nanonization of insoluble drugs to obtain the nanosized CBD suspension. In the nanosized CBD suspension, nanosized CBD has high solid content. The nanonization method for the CBD achieves solubilization of the CBD.

Dissolving microneedle containing cannabidiol suspension and preparation method thereof

A method and an apparatus for setting an evacuation exit under a crowd emergency evacuation scenario are provided. A simulation model is constructed based on a social force model, and a behavior parameter of an evacuating crowd under the crowd emergency evacuation scenario is obtained by a numerical approximation method with actual trajectory data of individuals in the evacuating crowd under a specific emergency evacuation scenario as a reference; an evacuation exit set is set, an integer programming solution for evacuation exit decision under the emergency evacuation scenario is constructed, and a total evacuation cost of the evacuation exit is obtained based on the simulation model; and reduction of the total evacuation cost is taken as an optimization target to construct an emergency evacuation optimization model based on constraint conditions, and the emergency evacuation optimization model is solved to obtain a recommended integer programming solution for evacuation exit decision.

Method and apparatus for setting evacuation exit under crowd emergency evacuation scenario

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Beijing, China

Han Liu