Massachusetts Institute of Technology

The Broad Institute, Inc.

Han Altae-Tran

Feng Zhang

Omar O Abudayyeh

Jonathan S Gootenberg

Alim Ladha

Guilhem Faure

Julia Joung

Linyi Gao

Soumya Kannan

Described herein are systems, methods, and compositions capable of targeting nucleic acids. Describe in certain exemplary embodiments herein are a class of small Cas proteins (Type II-D Cas proteins) and systems thereof. Also described in certain exemplary embodiments herein are methods of modifying target sequences using the class of small Cas proteins (Type II-D Cas proteins) and systems thereof described herein.

Small type II-D Cas proteins and methods of use thereof

Novel programmable targeting sequences and applications thereof. The targeting sequences can be engineered for binding to proteins, polypeptides, and other macromolecules.

Target recognition motifs and uses thereof

Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.

Rapid diagnostics

Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.

Type V CRISPR-Cas systems and use thereof

Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.

Growing community of inventors

Cambridge, MA, United States of America

Han Altae-Tran