Sanford Burnham Prebys Medical Discovery Institute

University of Central Florida Research Foundation, Inc.

Memorial Sloan Kettering Cancer Center

Sanford Burnham Prebys Medical Discovery Institute at Lake Nona

University of Pennsylvania

Hampton Sessions

Anthony B Pinkerton

Charalambos Kaittanis

Santimukul Santra

Annette Khaled

Satyamaheshwar Peddibhotla

Eduard A Sergienko

Jan Grimm

Jesus Manuel Perez Figueroa

Oscar Santiesteban

Stephen Gardell

Teresa Leone

Daniel Kelly

Byungyong Ahn

Richard Vega

Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include SBI-477 and compounds based on SBI-477 i.e., SBI-477 analogs (collectively, SBI-477 compounds) and/or Mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition. Also disclosed are methods of reducing intracellular lipid accumulation and/or increase glucose uptake in a subject in need thereof. The method includes administering to the subject an effective amount of SBI-477 compounds and/or Mondo family inhibitor to reducing intracellular lipid accumulation and/or increase glucose uptake in the subject. Also disclosed are method for treating one or more Myc-driven cancers, including neuroblastoma, lung squamous cell carcinoma/lung adenocarcinoma, liver hepatocellular carcinoma, colon adenocarcinoma, acute myeloid leukemia, and breast invasive carcinoma.

Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof

Provided herein is a nanoparticle for drug delivery, wherein the nanoparticle comprises a hyperbranched polyester (HBPE) nanoparticle having a hydrophobic interior, polyglutamate folate ligands conjugated to the nanoparticle, and one or more PET detectable isotopes. Also provided herein are methods of using thereof.

Methods and compositions for theranostic nanoparticles

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof

Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.

Growing community of inventors

Orlando, FL, United States of America

Hampton Sessions