Polium Technologies, Inc.

Hamilton J Lenox

Mikhail Y Gololobov

Elena Terentieva

(R)-6F-phenylephrine, essentially free of (S)-6F-phenylephrine, and an anesthetic formulation comprising (R)-6F-epinephrin or (R)-6F-phenylephrine and having improved stability compared to formulations containing their non-fluorinated analog, are disclosed. Further disclosed is a method of providing vasoconstriction in a mammal by administering the anesthetic formulation. The anesthetic composition can include an anesthetic, an (R)-chiral compound having the structure:wherein R, R, and Rare independently selected from &#x2014;H or &#x2014;F, at least one of R, R, and Ris &#x2014;F, and Ris selected from &#x2014;OH, &#x2014;H or &#x2014;F, or a pharmaceutically acceptable salt or ester thereof, said vasoconstrictor being essentially free of the (S)-chiral form. Also, a method of chiral addition of cyanide to a ring-fluorinated phenaldehyde, employing an almond hydroxynitrile lyase enzyme, provided in the form of a reversibly soluble polymer conjugate ((R)-Finezyme&#x2122;-H series biocatalysts) is disclosed. Several such biocatalysts are disclosed.

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Chicago, IL, United States of America

Hamilton J Lenox