University of Utah Research Foundation

University System of Maryland

Rexahn Pharmaceuticals, Inc.

Hamidreza Ghandehari

Joseph Cappello

Glenn D Prestwich

Young Bok Lee

Deog Joong Kim

Chang Ho Ahn

Wanjian Jia

Abhijit Ray

Siam Oottamasathien

Robert Andrew Price

Mark Martin Jensen

Joshua Gustafson

Azadeh Poursaid

Anjan Nan

Harlan R Muntz

Bhuvanesh Kumar Yathavan

Venkata K Yellepeddi

Seyyed Pouya Hadipour Moghaddam

Nancy Alice Murphy

Kevin Watt

Jordan Frandsen

Khaled Greish

Disclosed herein are methods and compositions comprising atropine and a polymer in a gel formulation for decreasing saliva production and treating sialorrhea.

Compositions and methods for treating sialorrhea

Described herein are in situ gelling compositions. The compositions include an anti-inflammatory polysaccharide and a gelling polymer, wherein the composition is a liquid prior to administration to a subject but converts to a gel upon administration to the subject. The compositions described herein have numerous applications with respect to the local treatment (reduction or prevention) of inflammation and/or tissue damage.

In situ gelling compositions for the treatment or prevention of inflammation and tissue damage

The disclosure extends to biodegradable hollow nanoparticles, and systems, methods, devices, and processes for producing the same. The disclosure includes a method of preparing a hollow mesoporous nanoparticle by providing a plurality of silica core particles. Each of the plurality of silica core particles comprises a diameter within a range of about 600 nanometers to about 30 nanometers. The method further includes synthesizing a mesoporous silica shell around the plurality of silica core particles forming a plurality of mesoporous coated silica core particles. Further, the method provides for etching the plurality of mesoporous coated silica core particles with an aqueous solution of sodium carbonate and water to remove the silica core particle from the plurality of mesoporous coated silica core particles forming a plurality of hollow mesoporous particles. The method also includes diffusing a payload into the plurality of hollow mesoporous particles in an aqueous solution.

Biodegradable hollow nanoparticles and methods and apparatus for manufacturing the same

A delivery system that includes a recombinantly synthesized protein polymer with protease cleavage sites such as matrix metalloproteinase responsive sequences engineered within the protein polymer. The system may be used to treat cancer, wounds, or pathological conditions in other tissues that express excess protease relative to healthy tissue.

Matrix metalloproteinase cleavable protein polymers for cancer gene therapy

A chemoembolic agent is disclosed that includes an injectable, recombinantly synthesized silk-elastin like protein copolymer and one or more chemotherapeutic agents. Upon injection, the chemoembolic agent blocks the tumor vasculature, including the capillary bed, and may optionally release chemotherapeutic agents. The chemoembolic agent may be used to treat cancer, including hepatocellular carcinoma.

Silk-elastin like protein polymers for embolization and chemoembolization to treat cancer

Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.

HPMA&#x2014;docetaxel conjugates and uses therefore

Growing community of inventors

Salt Lake City, UT, United States of America

Hamidreza Ghandehari