Wisconsin Alumni Research Foundation

Hamid Reza Eghbalnia

Mark Eric Cook

Daniel Elmer Butz

Warren Paul Porter

Fariba Masoumeh Assadi-Porter

Marco Tonelli

The methods described herein are based on the observation that oscillations in breath isotope ratio data can be used for the purpose of identifying an 'unhealthy' state in an organism such as a human. Described herein are methods of determining the state of health of an individual, such as the transition from healthy to infected, by identifying changes in oscillation modes in breath isotope ratio data. Changes in the frequency and/or amplitude of the oscillation modes are correlated with the heath of the individual. The methods can advantageously be used to provide information about the health of an individual in shorter periods of time than previous methods.

Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios

The invention is methods and related kits for diagnosing a disease state of cachexia by measuring biomarker profiles from a biological sample. Rapid measurement of early onset or progression of the disease in a subject is determined by measuring biomarker levels from the subject and optionally comparing the biomarker levels to a standard biomarker profile or metabolome phase portrait for the disease. The biomarkers measured in the assay and related kit for cachexia progression include biomarkers selected from the group consisting of lactate, citrate, formate, acetoacetate, 3-hydroxy butrate, alanine, glutamine, glutamate, valine, isoleucine leucine, thrionine, lysine, arginine, tyrosine, phenyl alanine, histidine and tryptophan.

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Madison, WI, United States of America

Hamid Reza Eghbalnia