Amberstone Biosciences, Inc.

Roche Molecular Systems, Inc.

Genmark Diagnostics, Inc.

Hamed Shadpour

Sean Ford

Darren S Gray

George Guikai Wu

Per Niklas Hedde

Jorge Alberto Garces

The present invention provides improved methods that allow accurate monitoring and/or control of temperature changes in a microfluidic environment. An advantage of the present invention is that the temperature can be monitored and/or controlled at any location within a microfluidic device, especially where a preparation step, an amplification step and/or a detection step is performed. The invention further provides improved microfluidic devices for practicing the methods disclosed and claimed herein.

Devices and methods for monitoring and controlling temperature in a microfluidic environment

Provided are microfluidic systems and methods for detecting, sorting, and dispensing of low abundance events such as single cells and particles, including a variety of eukaryotic and bacterial cells, for a variety of bioassay applications. The systems and methods described herein, when implemented in whole or in part, will make relevant microfluidic based tools available for a variety of applications in biotechnology including antibody discovery, immuno-therapeutic discovery, high-throughput single cell analysis, target-specific compound screening, and synthetic biology screening.

Microfluidic determination of low abundance events

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Mission Viejo, CA, United States of America

Hamed Shadpour