King Saud University

Imam Abdulrahman Bin Faisal University

Hamad M Alkahtani

M Nasiruzzaman Shaikh

Mohamed Abdulrahman Al-Omar

Nagy Mahmoud Hassan Khalifa

Fadilah Sfouq Aleanizy

Haya A Abubshait

Sara Nabil Shaban

Asma Mohmmad Elsharif

Ahmed H Bakheit

Samar A Abubshait

A method of making a pyrazole compound includes mixing a diazonium salt with a reactant in the presence of a solvent, thereby coupling a diazo group of the diazonium salt to an α-carbon atom of the reactant to form a reaction intermediate having a formula of (I) or (II); mixing the reaction intermediate and hydrazine in the presence of a superparamagnetic iron oxide nanoparticles catalyst thereby cyclizing the hydrazine with an ester group of the reaction intermediate to form the pyrazole compound having a formula of (III) or (IV).

2-aminothiazoles derivatives and method of preparation thereof using super-paramagnetic iron oxide nanoparticles (SPIONs)

The pyrido[2,3-d]pyrimidine derivatives as anticancer agents include 5-(substituted-phenyl)-2-(3-methyl-5-oxo-2H-pyrazol-1(5H)-yl)-7-(pyridin-3-yl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives having the formula: where R is hydrogen; 2-halo, 3-halo, or 4-halo (Cl, Br, or F); 2-methoxy, 3-methoxy, or 4-methoxy (OCH); 2-nitro, 3-nitro, or 4-nitro (NO); 4-isopropyl, 4-methyl, or 4-cyano (CN); 2-hydroxy or 3-hydroxy (OH), 3-chloro and 5-chloro; 2-methoxy and 5-methoxy, 3-methoxy and 5-methoxy, or 3-methoxy and 4-methoxy; 3,4,5-trimethoxy; or 2-hydroxy and 4-hydroxy; or a pharmaceutically acceptable salt thereof. The derivatives may be useful in treating various cancers, including hepatic, colon, prostate, breast, and lung cancer.

Pyrido[2,3-d]pyrimidines as anticancer agents

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Riyadh, Saudi Arabia

Hamad M Alkahtani