University of California

Genentech, Inc.

Aventis Pharma S.a.

Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Pharma Kg

Hal V Barron

Elias Botvinick

Richard Chin

Erich Bluhmki

Fong Wang-Clow

Silvano Berioli

Christopher Granger

Paul Armstrong

Frederique Bigonzi

Frans Van De Werf

The invention concerns an improved therapeutic regimen for the treatment of thrombolytic disorders, such as acute myocardial infarction (AMI). In particular, the present invention concerns the treatment of thrombolytic disorders, e.g. AMI, with a combination of a tissue plasminogen activator (t-PA) variant having improved fibrin specificity and extended plasma half-life when compared with wild-type human t-PA and a low molecular weight heparin.

Combination treatment with t-PA variant and low molecular weight heparin

Compositions and methods for treatment of occlusive peripheral vascular disease and coronary disease are disclosed. The compositions and methods allow treatment of diseases associated with occlusion of coronary vessels, for example, by promoting growth of new blood vessels, i.e., angiogenesis and/or by recruitment of collaterals. The methods involve the co-administration of an adenosine A receptor agonist, e.g., adenosine, and heparin and/or a heparin-like substance over a period of several days. In particular, this invention is applicable to improving collateral coronary circulation in patients suffering from myocardial infarction.

Method for treating occlusive peripheral vascular disease and coronary disease

This invention relates to a method of promoting growth of new blood vessels, i.e., angiogenesis, by coadministration of an adenosine receptor agonist, e.g., adenosine, and heparin over a period of several days. In particular, this invention is applicable to promoting angiogenesis to improve collateral coronary circulation in patients suffering from myocardial infarction.

Method for promoting angiogenesis using heparin and adenosine

Growing community of inventors

San Francisco, CA, United States of America

Hal V Barron