Elekta Instrument Ab

Elekta Ab (publ)

Telefonaktiebolaget Lm Ericsson (publ)

University Health Network

Elekta, Inc.

Elekta Instruments Ab

Elekta Ab

Håkan Nordström

Jens Olof Sjölund

Stella Riad

Björn Somell

Paul Schliwa-Bertling

Hannes Ekström

Erik Westerberg

Ingo Meirick

Marcus Hennix

David Anthony Jaffray

Jonas Anders Adler

Gregory Bootsma

Markus Eriksson

Jonas Johansson

Joakim Wang Erlandsson

Fredrik Lundqvist

Jens Sjölund

Frank Verhaegen

Emil Norell

Bjorn Nutti

Karl Danielsson

Pär Lidberg

The present invention relates to the field of radiation therapy and methods, software and systems for treatment planning. A target volume of a region of a patient to be treated during a treatment of a patient in a radiation therapy unit is obtained. A first isocenter location procedure is performed including inter alia evaluating potential isocenter locations along normal directions of the surface and respective isodistance surfaces in respective starting voxels in a direction inwards from the surface, and a second isocenter location procedure is performed including inter alia identifying a median axis of the target volume or center point of the target volume, placing isocenters at locations along the median axis, and placing isocenters in the target volume based on a distance to existing isocenters and to the target surface.

Treatment planning

A method for treatment planning for a radiation therapy system includes setting a number of objectives reflecting clinical criteria are set for the regions of interest and generating radiation dose profiles to be delivered to these regions of interest. A convex optimization function for optimizing the delivered radiation based on the objectives is provided and dose profiles for specific treatment configurations including beam shape settings for the radiation dose profiles are calculated using the convex optimization function. Treatment plans including determining the radiation dose profiles to be delivered during treatment based on the treatment configurations are created and an optimal treatment plan that satisfies the clinical criteria is selected.

Convex inverse planning method

Methods for dose or treatment planning for a radiotherapy system including a radiotherapy unit are provided. A spatial dose delivered can be changed by adjusting beam shape settings, and the delivered radiation is determined using an optimization problem that steers the delivered radiation according to objectives reflecting criteria for regions of interest including at least one of: targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes determining an inner set of voxels and providing a first frame description for the inner set of voxels, where the first frame description reflects criteria for the inner set of voxels. Determining an outer set of voxels encompassing the target volume and the inner set of voxels and a frame description for the outer set of voxels is provided where each reflecting criteria for the outer set of voxels. The frame descriptions are then used in the optimization problem that steers the delivered radiation.

Methods for inverse planning

In the field of radiotherapy, methods for dose or treatment planning for a radiation therapy system having a collimator, includes determining shots to be delivered during said treatment, each shot being associated with an isocenter and being modelled by a spatial dose volume distribution of radiation, the shape of said spatial distribution depending on the specific collimator setting and said selected dose level, including selecting isocenter positions within a target in a predetermined angle range; evaluating each isocenter based on predetermined conditions; selecting at least a specific collimator and sector setting for each isocenter based on the evaluation; calculating a dose for the selected isocenters; repeating the steps until at least one stopping criteria has been reached, wherein a final set of isocenters are provided; and using the final set of isocenters in treatment planning.

Methods for treatment planning

In the field of radiotherapy, methods for dose or treatment planning for a radiotherapy system are disclosed, wherein a spatial dose delivered can be adjusted and delivered radiation is determined using an optimization problem that steers the delivered radiation according to a frame description reflecting criteria for regions of interest that include at least one of targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes estimating a voxel set receiving a higher dose than a predetermined threshold dose level, which voxel set includes voxels from at least one target volume. Further, a low dose voxel set is determined and a frame description for the voxels in the low dose voxel set is provided where voxels receiving a dose exceeding a predetermined threshold value is penalized such that the dose delivered to the low dose voxel set is suppressed. The frame description is then used in the optimization problem that steers the delivered radiation.

The present invention relates to the field of radiation therapy. In particular, the present invention relates to methods for treatment planning for a radiation therapy system. The method includes setting a number of objectives reflecting clinical criteria are set for the regions of interest and generating radiation dose profiles to be delivered to these regions of interest. A convex optimization function for optimizing the delivered radiation based on the objectives is provided and dose profiles for specific treatment configurations including beam shape settings for the radiation dose profiles are calculated using the convex optimization function. Treatment plans including determining the radiation dose profiles to be delivered during treatment based on the treatment configurations are created and an optimal treatment plan that satisfies the clinical criteria is selected.

Embodiments disclose a method performed by at least one processor for processing a plurality of x-ray projection images of a subject, the method comprising a plurality of operations including reconstructing the projection images to yield a volume reconstruction; segmenting the reconstructed volume by assigning a material type to each voxel; estimating a first set of scatter images corresponding to a subset of the projection images by calculating probabilistic predictions of interactions of x-rays with the subject and applying a low pass spatial filter to the scatter images; estimating a second set of scatter images corresponding to projection images not included in the subset, based on the first set of scatter images; and subtracting, for each projection image, the corresponding scatter image to yield a corrected projection image. Applying the plurality of operations of the method in an iterative process on graphics-processor-quality computational hardware enables real-time scatter correction and reconstruction of CT volume images.

Target-specific dose and scatter estimation in CT images

A method and a dose planning module for planning a treatment session of a patient by means of a radiation therapy system includes a radiation therapy unit having a fixed radiation focus point. The method includes obtaining a target volume of a region of a patient to be treated during a treatment of a patient in a radiation therapy unit, the target volume being modeled as a three-dimensional voxel representation; selecting an isodose level for the planned treatment; determining shots to be delivered during the treatment, each shot being modeled by a spatial dose volume distribution of radiation represented by a three-dimensional voxel representation, the shape of the spatial distribution depending on the specific collimator setting and the selected isodose level; and selecting shots in a decreasing volume order for the dose planning.

Effective volume filling with templates

A method for planning a treatment session of a patient and optimizing the treatment time for a treatment using a radiation therapy system includes a radiation therapy unit having a fixed radiation focus point. During an optimization of a treatment plan for a patient, a set of shots to be delivered to a plurality of isocenter positions within a target volume of a patient during a treatment session are determined and a beam-on time for each respective sector and state for each isocenter during which radiation is to be delivered are determined based on the treatment plan. For each isocenter position, sectors and states of respective sector are grouped in accordance predetermined rules with respect to beam-on times for respective state of the sectors, wherein sectors and respective states are aggregated for simultaneous delivery of radiation during a predetermined period of time.

Sequencing sector fields

The technology described relates to management of data packets and buffers comprising segments of data packets in a mobile communication system. Information associated with data packet segments is analyzed by a Base Station System (BSS) housing a data buffer. Based on this information analysis, the BSS can identify those segments in the buffer that constitute a complete data packet. Once identified, the segments can be discarded from the buffer. The information can include size information, whereby the analysis comprises pairwise comparing the size of a current segment with the size of a next consecutive segment. This size comparison enables identification of a first segment and a last segment of the complete data packet. The information could also, or alternatively, include a notification provided in the header of the segment. This notification identifies the associated segment as the first or last segment of the data packet or an intermediate segment.

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Sollentuna, Sweden

Håkan Nordström