Doxa Ab

Doxa Aktiebolag

Cerbio Tech Ab

Håkan Engqvist

Leif Hermansson

Niklas Axén

Lars Kraft

Nils-Otto Ahnfelt

Niklas Axen

Jesper Lööf

Tobias Persson

Kajsa Björklund

Jesper Loof

Jan-Erik Schulz-Walz

Irmeli Hermansson

Gunilla Gomez-Ortega

Håkan Spengler

The present invention relates to ceramic precursor material exhibiting injectability and properties that make the material suitable as a carrier material used in drug delivery. According to the invention this is accomplished by selecting a microstructure based on pre-reacted phases and after injection established phases, which contain anti-infective and/or anti-inflammatory drugs. The present invention also relates to a cured ceramic material and a method of manufacturing said cured material. The precursor and the cured ceramic material according to the present invention can suitably be used for filling orthopaedic cavities and other bone voids.

Drug implant carrier for drug delivery

Ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and a composite biomaterial suitable for orthopaedic applications. The CBC-system includes a binding phase (chemical cement) and additional phases with specified chemistry imparting to the biomaterial the ability of initial strength followed by interaction with the body tissue including body liquid, to form a resorbable or partly resorbable biomaterial. The ceramic precursor composition includes at least one silicate with Ca as the main cation with a resorption rate less or equal to that of the bone in-growth rate. The silicate will form the binding phase of the cured material. Implants and surface coated devices are also disclosed. The cured material exhibits a compressive strength exceeding 100 MPa.

Resorbable ceramic compositions

A dental cement system, including an aqueous hydration liquid and a powdered material that essentially consists of an inorganic cement system, which powdered material has the capacity to form a complex, chemically bonded material with inorganic as well as organic phases with properties suitable for cementation of implant to another implant and/or to tooth or bone tissue.

Dental cement system, a powdered material and a hydration liquid therefor, and ceramic material formed therefrom

A system for a dental filling material or an implant material, alternatively a system for bonding between a tooth or a bone and a dental filling material and a implant material, respectively, which system comprises a water based hydration liquid and a powdered material, the binder phase of which powdered material essentially consisting of a calcium based cement system, which powdered material has the capacity following saturation with the liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, said powdered material and/or said hydration liquid comprises water soluble phosphate or a phase that has the capacity to form water soluble phosphate, whereby the system exhibits the capacity during hydration to form apatite. The invention also relates to the powdered material and the hydration liquid as such, an implant material and a method of achieving bonding.

System for a dental filling material or implant material, and powdered material, hydration liquid, implant material and method of achieving bonding

The present invention deals with the initial hydration reaction of highly alkaline chemically bonded ceramic systems such as Ca-aluminate and Ca-silicate, exhibiting a controlled pH development, reduced from very high levels to be in a pH range of 7-9 by the use of an internal buffer system added to the CBC type biomaterial used. The invention is especially intended for endodontic, orthopaedic applications and/or soft tissue applications and/or drug delivery carrier applications.

Powdered CBC system with improved reaction feature

A chemically bonded biomaterial element composed of an inorganic cement, exhibiting minimal dimensional changes upon hardening and long-time use, improved mechanical properties and improved translucency. An algorithm to describe the micro-structure is expressed as where &#x3bb; is the distance between filler particles of mean size d, and Vis the volume content of non-reacted cement and added filler, and where &#x3bb;&#x2266;10 &#x3bc;m. The invention also relates to a device in connection with the preparation of a chemically bonded biomaterial element according to the invention.

Chemically bonded biomaterial with tailored properties

Powdered material, the binder phase of which mainly consists of a cement-based system, which powdered material has the capacity following saturation with a liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material, preferably for dental purposes. According to the invention the powdered material has a composition and/or structure suitable for giving the ceramic material translucence in the hydrated state. The invention also relates to the ceramic material produced by hydration of the powdered material.

Powdered material and ceramic material manufactured therefrom

The invention describes a low temperature method for producing multi-layered or multi-phased coatings. With the technique according to the present invention, surface coatings with controlled variations in terms of chemical composition, phase composition, porosity, surface roughness, mechanical properties, biocompatibility, etc can be achieved. The method of coating a substrate surface comprising the steps of preparing one powder mixture, or several powder mixtures having different chemical composition, wherein at least one of said powder mixtures comprise a non-hydrated hydraulic ceramic powder binder phase, pre-treating a substrate surface, to increase the adhesion between the substrate and the ceramic coating, applying one or more different layers on top of each other of the non-hydrated powder mixture on the substrate, and finally, hydrating the powder layer/layers in a curing agent containing ions of carbonates, phosphates or fluorides.

Growing community of inventors

Knivsta, Sweden

Håkan Engqvist