Auransa Inc.

Hak Jin Chang

Andrew Asher Protter

Pek Yee Lum

Sarvajit Chakravarty

Michael J Green

Son Minh Pham

Gregory R Luedtke

Sidney Paul Elmer

Anna Halberg

Rajaa Sukhun

The present disclosure provides a group of aromatic (e.g., pyridinyl, pyrimidinyl, pyrazinyl, or phenyl) diamidine analogs and pharmaceutically acceptable salts that are useful for treating a proliferative disease. The proliferative disease may include solid cancer or blood cancer. Compositions, methods of synthesizing the same and methods for treating various cancer using the analogs are disclosed herein. The present disclosure also provides pharmaceutical formulations comprising at least one of the compounds with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Analogues of pentamidine and uses therefor

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to processes for preparing the same; a pharmaceutical composition and formulation containing a derivative of piperlongumine; and use of the derivatives and analogs for treating cancer.

Derivatives of piperlongumine and uses thereof

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Harvard, MA, United States of America

Hak Jin Chang