Korea Institute of Science and Technology

Hak-Cheol Kwon

Sung-Kwon Chung

Hyun-Ok Yang

Myung-soo Kim

Jin-Soo Park

Na-Young Bae

Myung-Sook Oh

Provided are novel use of an extract ofor a compound isolated therefrom for inhibition of &#x3b2;-amyloid production and/or prevention, improvement and/or treatment of a neurodegenerative disease, more specifically a &#x3b2;-amyloid production inhibitor, and/or a composition for prevention or treatment of a neurodegenerative disease containing one or more kinds selected from the group consisting of an extract of, and/or dihydrolycoricidine, 2-methoxypancracine, lycoricidine, and/or lycoricidinol, as an active ingredient; a method for inhibiting &#x3b2;-amyloid production, and/or preventing and/or treating a neurodegenerative disease using the same; and, a method for preparing the same.

[object Object]

This disclosure relates to a composition for prevention or treatment of neurodegenerative disease comprising longan arillus extract, or combined extract comprising longan arillus. The composition exhibits remarkably excellent prevention or treatment effect of neurodegenerative disease by containing longan arillus extract or combined extract comprising longan arillus, and particularly, it may effectively prevent or treat neurodegenerative disease by significantly protecting dopaminergic neurons from neurotoxicity due to MPTP selectively acting on dopaminergic nervous system and neurotoxicity due to aggregation of alpha-synuclein proteins.

Growing community of inventors

Seoul, South Korea

Hak-Cheol Kwon