Egis Gyogyszergyar Rt.

Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

Egis Gyogyszergyar

Egis Gyogyszergyar Nyrt

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Gyula Simig

Gabor Gigler

Jozsef Barkoczy

Istvan Gacsalyi

József Barkóczy

Balázs Volk

György Lévay

Gábor Szénási

Péter Kótay Nagy

István Gacsályi

Éva Schmidt

András Egyed

Gábor Gigler

Csilla Leveleki

János Wellmann

Szabolcs Kertesz

László Hársing

Bernadett Martonné Markó

Gabor Szenas

Lászlo Gabor Harsing

György Levay

Ferenc Bertha

Marta Agoston

Gyoergy Levay

József Barkoczy

Gábor Szenasi

István Gacsalyi

Márta Agoston

László Gábor Harsing

Péter Kiricsi

László Gábor Hársing

Bernadett Markó

Balázs Molnar

József Fetter

József Schindler

Katalin Pallagi

Ildikó Nagyné Gyönös

Elemér Fogassy

Katalin Nagy

The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone of the Formula (I) or pharmaceutically acceptable salts thereof for the preparation of medicaments suitable for the improvement of cognitive function or obtaining neuroprotective effect. The medicaments containing 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazol-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone of the Formula (I) or therapeutically acceptable salt thereof can be used for the treatment or prevention of neuronal death, mental decline, sclerosis multiplex, Creuzfeld-Jacobs disease, Huntington-syndrome, amyotrophic lateral sclerosis, Parkinson-disease, memory disturbance, loss of memory, amnesia, stroke or for the improvement of memory function or learning ability.

Medicament for the enhancement of cognitive function and neuroprotection

The invention relates to substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein Ris hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), Ris hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Rstands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(Calkyl); Z stands for oxygen; or Rand Z together with the groups placed between them form a piperazine ring; and Rstands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.

Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

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Budapest, Hungary

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