Maruko Seiyaku Co., Ltd.

Mitsui Norin Co., Ltd.

Hajimu Yamamoto

Sachio Ohno

Kiyoshi Mizukoshi

Yukihiko Hara

Mikio Hori

Mitsuaki Nagasaka

Osamu Komatsu

Kazuo Kato

Yoshiki Nakamura

Kazuo Okushio

Hajime Asai

Kozo Nakamura

Tadashi Kitamikado

Kihachiro Izumi

Yasuo Kunou

Extract of tea leaves or (-)-epigallocatechin gallate as the principal ingredient of the extract forms a complex with active aluminum hydroxide. The animal test using rats has established that these complexes have therapeutic effect for gastric ulcers, e.g. pylorus-ligated ulcer and indomethacin-induced ulcer, when orally administered. Tests were also undertaken for the effect on the secretion of gastric juice and acute toxicity of these complexes using rats and mice as the test animals.

Complex of tea-leaf extract and active aluminum hydroxide

Novel thiopyranopyrimidine compounds and the pharmaceutically acceptable acid addition salts thereof having excellent hypoglycemic activity, platelet aggregation inhibitory activity, antihistamine activity and anti-allergy activity useful for prevention and treatment of various disorders caused by diabetes, allergy and the like are disclosed.

Thiopyranopyrimidine compounds and acid addition salts thereof

Cis or trans-1,5-benzothiazepine compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and R.sub.2 represents a hydrogen atom, an alkyl group or a hydroxyalkyl group and the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof which exhibit anticholinergic activity and are useful as anti-ulcer, gastric secretion inhibiting and antispasmodic agents in mammals, and a process for preparing the same.

1,5-Benzothiazepine compounds

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Nagoya, Japan

Hajimu Yamamoto