Asahi Kasei Kogyo Kabushiki Kaisha

Dainippon Pharmaceutical Company, Limited

Hajimu Sakamoto

Hiroshi Hayashi

Akio Hasegawa

Takao Kiyota

Sadayuki Horiguchi

A method for stabilizing a Tumor Necrosis Factor (TNF), which comprises adding at least one member selected from the group consisting of an albumin, a gelatin, a globulin, a protamine and a salt of protamine to an aqueous solution or powder containing TNF, and a stable aqueous solution or powder which contains TNF and an effective amount of such a protein. The aqueous solution or powder containing TNF can be stored for a prolonged period of time without losing its activity, and is stable on freezing, thawing, lyophilization or the like.

Method for stabilizing a tumor necrosis factor and a stable aqueous

In the production of plasminogen activator from animal cells in a nutrient solution, the addition of a large amount of fumaric acid, malic acid, succinic acid, and/or glycolic acid to the nutrient solution brings about a 30 to 180% increase in the amount of plasminogen activator produced.

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Fuji, Japan

Hajimu Sakamoto