Asai Germanium Research Institute Co., Ltd.

Asai Germanium Research Institute

Hajime Orimo

Norihiro Kakimoto

Kohei Miyao

Hiroshi Satoh

The present invention provides (a) an activator for osteoblast comprising, as an active ingredient, a salt between (1) an organogermanium compound represented by the formula (I) ##STR1## [in the above formula (I), R.sub.1, R.sub.2 and R.sub.3 which may be the same or different, are independently a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like, or an aryl group] and (2) a basic group-containing compound, and (b) a method for activating osteoblasts, which comprises administering in need of such treatment an effective amount of a salt between an organogermanium compound represented by the above formula (I) and a basic group-containing compound.

Activator for osteoblasts

This invention provides remedies for bone diseases characterized by comprising organogermanium compounds expressed by the following formula: ##STR1## (wherein R.sub.1, R.sub.2 and R.sub.3 respectively denote a hydrogen atom, a lower alkyl group such as a methyl or ethyl group, or a substituted or non-substituted phenyl group; X denotes a hydroxyl, O-lower alkyl or amino group; and Y denotes an oxygen or sulfur atom) as an effective ingredient. These remedies are effect for the remedy of osteoporosis.

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Tokyo, Japan

Hajime Orimo