Fujirebio Inc.

Fujirebio Kabushiki Kaisha

Kabushiki-kaisha Toy Box

Hajime Matsumoto

Yasuo Sekine

Hiroshi Ikawa

Akihiko Hosoda

Noriaki Kashiwaba

Yoshikazu Isowa

Akihiro Sekine

Tetsuaki Yamaura

Masashi Nishikawa

Nobuhiko Hirakawa

Nobuo Kobayashi

Masakatsu Matsumoto

Masato Nishimura

Teruo Kutsuma

Jun Kusunoki

Hisako Harada

Tetsuaki Yamura

Nobuhiro Hirakawa

Sousuke Oriya

A method of producing a pantothenic acid derivative of formula (I): ##STR1## wherein each of R.sup.1 and R .sup.2 is different, and is a branched aliphatic hydrocarbon group having 3 to 5 carbon atoms, or a phenyl group; or a straight chain aliphatic hydrocarbon group having 5 to 10 carbon atoms, is provided, including methods of producing the starting materials for producing the same and novel amine derivative that can be used for the production of the pantothenic acid derivative.

Methods of producing pantothenic acid derivative and its starting

A method of producing a pantothenic acid derivative of formula (I): ##STR1## wherein each of R.sup.1 and R.sup.2 is different, and is a branched aliphatic hydrocarbon group having 3 to 5 carbon atoms, or a phenyl group; or a straight chain aliphatic hydrocarbon group having 5 to 10 carbon atoms, is provided, including methods of producing the starting materials for producing the same and novel amine derivative that can be used for the production of the pantothenic acid derivative.

A method of producing an aminobutene derivative of formula (I) by allowing a butenol derivative of formula (II) to react with an amide derivative of formula (III) is disclosed. The aminobutene derivative of formula (I) can be deprotected to produce an aminobutene derivative of formula (I-1) or an aminobutene derivative of formula (I-2): ##STR1## The aminobutene derivative of formula (I-A) can also be deprotected to produce the aminobutene derivative of formula (I-B). Any or all of the above aminobutene derivatives are useful as intermediates for producing anti-ulcer drugs, and anti-ulcer drugs having an inhibitory effect on gastric acid secretion based on the antagonism against histamine H.sub.2 receptor.

Methods of producing aminobutene derivatives

Compounds represented by general formula (I) below ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group;

Pantothenic acid derivatives

A motorized toy system having current collectors, movable up and down via an elastic member incorporated into a body of the motorized toy. The current collectors protrude on right and left sides of the body and slidably and uniformly contact pole plates disposed on upper end surfaces of side walls formed on both sides of a track. Permanent magnets are disposed at constant intervals on the track so as to alternate their polarities, and the permanent magnets are secured to a first yoke. Electromagnets are mounted in the body, and are secured to a second yoke.

Motorized toy system

A phenoxypropyl derivative represented by the following formula ##STR1## wherein A represents a formyl group, a protected formyl group, a hydroxymethyl group, a protected hydroxymethyl group, or a halomethyl group, and Z represents a halogen atom, an amino group, a phthalimide group or a group of the formula ##STR2## in which n is 0, 1 or 2.

Phenoxypropyl derivatives

The compounds of the formulas (VI) and (VII) are useful intermediates in producing pyridyloxy derivatives of the formula (I), such as, for instance, N-{4-[4-(piperidinomethyl)pyridyl-2-oxy]-2-butenyl}-2-(furfurylt hio)acetamide, which are useful as anti-peptic ulcer agents. The compounds of formula (VI) have the formula ##STR1## wherein A represents a formyl group, a protected formyl group, a hydroxymethyl group or a protected hydroxymethyl group. The compounds of formula (VIII) have the formula ##STR2## wherein G represents a formyl group, a protected formyl group, a hydroxymethyl group, a hydroxymethyl group in which the hydroxyl group is protected, or a halogenomethyl group, Y represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2.

Intermediates for pyridyloxy compounds having utility as anti-peptic

A compound represented by the following formula or a salt thereof ##STR1## wherein each of R.sub.1 and R.sub.2 represents a lower alkyl group, or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are bonded, may form a substituted or unsubstituted, saturated or partially unsaturated 4- to 8-membered heterocyclic group which may contain a hetero atom selected from N, O and S, Y represents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2. This compound is useful as anti-peptic ulcer agent.

4-aminomethyl-pyridyl-2-oxy derivatives having anti-ulcer activity

Alkylamide derivatives having the formula, These compounds have a strong antiulcer action depend on histamine H.sub.2 -receptor antagonistic action and a cytoprotective action upon gastric mucous membrance.

Growing community of inventors

Hino, Japan

Hajime Matsumoto