Mitsubishi Tanabe Pharma Corporation

Hajime Hiramatsu

Akira Kubo

Ritsuo Imashiro

Tetsu Nakane

Hidetaka Miyoshi

Akihito Ogasawara

Tatsuo Nakajima

Hiroaki Sakurai

Kiyoshi Kyono

Hideaki Shima

Shigeru Sugiyama

The present invention relates to a compound of the formula [I]: wherein Gis an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: wherein ring B is benzene ring which may be substituted, etc., Q1 and Q2 may be the same or different, and each is hydrogen atom, a halogen atom or an alkyl, n is 0, 1, 2, 3 or 4, Ris hydrogen atom, an alkyl which may be substituted, a cycloalkyl which may be substituted, a phenyl which may be substituted, etc., Z, Z, Zand Zmay be the same or different, and each is CH or N, provided that 3 or more of Z, Z, Zand Zshould not be N at the same time, Gis hydrogen atom, &#x2014;NRR, &#x2014;OR, etc., where Rto Reach is independently hydrogen atom, an alkyl which may be substituted, an alkenyl, an alkynyl, etc., or a pharmaceutically acceptable salt thereof.

4-imidazolin-2-one compounds

A crystal of a dipeptidyl peptidase IV; a three-dimensional structural coordinate of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional coordinate of a homolog protein of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional structural coordinate of a crystal of a complex of the dipeptidyl peptidase IV and an effector of the dipeptidyl peptidase IV; a method for identifying pharmacophore of the effector of the dipeptidyl peptidase IV; a method for designing, identifying, evaluating or searching; the effector; and a program and a medium therefor for use of the three-dimensional structural coordinate.

Three-dimensional structure of dipeptidyl peptidase IV

The present invention relates to a compound of the formula [I]:  

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Ashiya, Japan

Hajime Hiramatsu