Taisho Pharmaceutical Co., Ltd.

Nissan Chemical Industries Limited

Hajime Asanuma

Masakazu Sato

Katsuo Hatayama

Hiroyuki Kakinuma

Tetsuo Takayama

Sadakazu Yokomori

Yutaka Ohuchi

Shoichi Kuroda

Masaji Suzuki

Nagaaki Sato

Hirofumi Ota

Tetsuya Yabuuchi

Hideaki Amada

Takumi Okada

Tomomichi Chonan

Takeshi Koami

Yudai Imai

Shigetada Sasako

Keiko Fusegi

Takanori Kawaguchi

Masahiro Bohno

Yoshihiko Isobe

Makoto Muramatsu

Shin Itoh

Seishi Ishiyama

Naoya Ono

Yuko Tsuchiya

Shigeru Tokita

Yoshinori Sekiguchi

Takahiro Oi

Fumiyasu Shiozawa

Yusuke Oka

Keishi Hayashi

Madoka Kawamura

Masabumi Shibuya

Fumito Uneuchi

Hironori Katakai

Daisuke Wakasugi

Hisaya Wada

Yuko Matsunaga

Noriko Saito

Rie Nishikawa

Souichi Monma

Takehiro Yamagishi

Chika Ito

Haruko Kijima

Akiko Ikeda

Hiroki Umemiya

Rui Jibiki

Kengo Watatani

Marie Mizutani

This 2-pyridone compound represented by formula [1] or a tautomer of said compound, or a pharmaceutically acceptable salt of said compound or said tautomer, or a solvate of said compound or the like has a superior GK-activating effect and is useful as a pharmaceutical. 

2-pyridone compound

A 2-pyridone compound represented by the formula [1]: {wherein in the formula [1],the ring represented by A represents a benzene ring or a pyridine ring,X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, andW represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)},a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

2-pyridone compounds

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.

Isoquinoline derivative

A thiazolylimidazole derivative represented by the formula or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient,wherein:  The present invention provides an inhibitory substance against ALK5 which is a TGF-&#x3b2; type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.

Thiazole derivative

There is provided a heteroaryl 5-thio-&#x3b2;-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, particularly a prophylactic or therapeutic agent for diabetes, diabetes-related diseases or diabetic complications, which comprises such a compound as an active ingredient. 

Heteroaryl 5-thio-&#x3b2;-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same

There is provided a 5-thio-&#x3b2;-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, particularly a prophylactic or therapeutic agent for diabetes, diabetes-related diseases or diabetic complications, which comprises such a compound as an active ingredient. 

Aryl 5-thio-&#x3b2;-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same

The present invention provides a method for preparing an aryl 5-thio-&#x3b2;-D-aldohexopyranoside derivative of Formula (III), which comprises reacting a 5-thio-D-aldohexopyranose derivative of Formula (I) with Ar-OH of Formula (II) in the presence of a phosphine represented by PRRRand an azo reagent represented by R&#x2014;N&#x2550;N&#x2014;Rin accordance with the following scheme 

Method for selective preparation of aryl 5-thio-&#x3b2;-D-aldohexopyranosides

Aminobenzoic acid derivatives

Quinolinecarboxylic acid derivatives

Endo-(8-methyl-8-azabicyclo�3.2.1!oct-3-yl) 1-isopropyl-2(1H)-quinolone-3-carboxylate represented by Formula (I): ##STR1## or an acid addition salt thereof acts on a serotonin 4 receptor thereby to have a serotonin-like receptor stimulating activity, therefore has an action on activating gastrointestinal motor functions and thus is effective for the improvement of gastrointestinal conditions such as heartburn, anorexia, bowel pain or abdominal distension accompanied by chronic gastritis or postoperative gastroparesis, and further for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction or constipation.

Heterocyclic compound

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Tokyo, Japan

Hajime Asanuma